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Journal ArticleDOI

The Growing Impact of Catalysis in the Pharmaceutical Industry

TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.
Abstract
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settings

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Citations
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Density Functional Theory-Inspired Design of Ir/P,S-Catalysts for Asymmetric Hydrogenation of Olefins

TL;DR: In this article, the authors gratefully acknowledge financial support from the Spanish Ministry of Science and Innovation (PID2019-104904GB-I00, PGC2018-100780-B-I 00, and PGC 2018-096616-B -I00), European Regional Development Fund (AEI/FEDER, UE), the Catalan Government (2017SGR1472), and the University of Alicante (VOGROB-316FI).
Journal ArticleDOI

Water-Resistant Photo-Crosslinked PEO/PEGDA Electrospun Nanofibers for Application in Catalysis

TL;DR: In this paper , a PEO/PEGDA blend with the Au/Pd catalyst is proposed as catalytic membranes for water phase and low-temperature reactions, and the resulting nanofibrous mat is able to maintain the nanostructure in water.
References
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Journal ArticleDOI

Palladium-catalyzed cross-coupling reactions of organoboron compounds

Norio Miyaura, +1 more
- 01 Nov 1995 - 
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI

The atom economy--a search for synthetic efficiency

TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI

Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.

TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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