Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
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Polydentate P, N-based ligands for palladium-catalyzed cross-coupling reactions
A. Rajmane,Arjun Kumbhar +1 more
TL;DR: A compressive review of the Pd-catalyzed C-C and C-X cross-coupling reactions with N and P as a donor atom can be found in this article .
Journal ArticleDOI
Solid‐Supported Catalysts for Organic Functional Group Transformations
Sodiq Adeyeye Nafiu,Afnan M. Ajeebi,Huda Saeed Alghamdi,Md. Abdul Aziz,M. Nasiruzzaman Shaikh +4 more
TL;DR: Solid-supported metal catalysts (SSMCs) as discussed by the authors have made an increasingly important contribution to heterogeneous catalysis in terms of fundamental understanding and technological applications, such as high thermal stability, dispersion, high exposed surface area, and above all, high reusability.
Journal ArticleDOI
Iron-Based Tandem Catalysis: From Petroleum toward Pharmaceutical Laboratories for Organic Undergraduate Students─Product Identification by TLC and 1H NMR
Lisa Smith,D. Udayanga,Xiaolin Qian,Lauren Adams,Sarah Sims,Charles B. Nettles,Xuechun Xu,Xin Cui,Debra Mlsna +8 more
TL;DR: In this paper , an experiment demonstrating iron-based tandem catalysis was developed and implemented in an organic chemistry course for second-year and upper-division undergraduate students at Mississippi State University, where the experiment uses TLC and 1H NMR to track the reaction and identify the core pharmaceutical structure produced during the experiment.
Journal ArticleDOI
Stereoselective Synthesis and Applications of Pinane-Based Chiral 1,4-Amino Alcohol Derivatives
TL;DR: In this article , a new library of pinane-based 1,4-amino alcohols was synthesised and utilised as chiral ligands in enantioselective diethylzinc addition to benzaldehyde.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
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Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
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Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
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Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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