Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Journal ArticleDOI
High-Performance Isocyanide Scavengers for Use in Low-Waste Purification of Olefin Metathesis Products.
Grzegorz Szczepaniak,Katarzyna Urbaniak,Celina Wierzbicka,Krzysztof Kosiński,Krzysztof Skowerski,Karol Grela +5 more
TL;DR: A new hybrid purification method is devised, which gives better results than using either a self-scavenging catalyst or a scavenger alone, and isocyanide II is shown to be a deactivating (reaction quenching) agent for olefin metathesis and superior to ethyl vinyl ether.
Journal ArticleDOI
An Improved Synthesis of BrettPhos‐ and RockPhos‐Type Biarylphosphine Ligands
TL;DR: Improved processes for the preparation of biphenyl-based phosphine ligands t-BuBrettPho, RockPhos, and BrettPhos are presented, featuring the use of Grignard reagents and catalytic amounts of copper that allow for the isolation of pure products in high yield.
Journal ArticleDOI
A theoretically-guided optimization of a new family of modular P,S-ligands for iridium-catalyzed hydrogenation of minimally functionalized olefins.
Jèssica Margalef,Xisco Caldentey,Erik A. Karlsson,Mercè Coll,Javier Mazuela,Oscar Pàmies,Montserrat Diéguez,Miquel A. Pericàs +7 more
TL;DR: A library of modular iridium complexes derived from thioether-phosphite/phosphinite ligands has been evaluated in the asymmetric iridium-catalyzed hydrogenation of minimally functionalized olefins, showing excellent enantioselectivities for a range of substrates.
Journal ArticleDOI
Pd-Catalyzed Cross-Coupling Reactions Promoted by Biaryl Phosphorinane Ligands
Summer D. Laffoon,Vincent S. Chan,Michael G. Fickes,Brian J. Kotecki,Andrew R. Ickes,Jeremy J. Henle,José G. Napolitano,Thaddeus S. Franczyk,Travis B. Dunn,David M. Barnes,Anthony R. Haight,Rodger F. Henry,Shashank Shekhar +12 more
TL;DR: Using the synthetic strategy described above, a library of biaryl phosphorinanes was synthesized, varying their substitution about phosphorus and the steric and electronic nature of the biaryl motif, and their performance as ligands in Pd-catalyzed cross coupling reactions such as aryl sulfonamidation, aryL alkoxylation, and aryal amination in the presence of soluble organic bases was benchmarked.
Journal ArticleDOI
The chemistry of the carbon-transition metal double and triple bond: Annual survey covering the year 2011
TL;DR: A review of papers published in the year 2011 that focus on the synthesis, reactivity, or properties of compounds containing a carbon-transition metal double or triple bond can be found in this article.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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