Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Journal ArticleDOI
Palladium-Catalyzed Cross-Couplings by C-O Bond Activation.
Tongliang Zhou,Michal Szostak +1 more
TL;DR: Although the field has been historically dominated by nickel catalysis, it is now evident that the use of more versatile, more functional group tolerant and highly active palladium catalysts supported by appropriately designed ancillary ligands enables the cross-coupling with improved substrate scope and generality, and likely represents a practical solution to the broadly applicable cross- coupling of various C-O bonds across diverse chemical disciplines.
Journal ArticleDOI
Supramolecularly fine-regulated enantioselective catalysts
TL;DR: Different supramolecular strategies to generate a set of enantiopure ligands (or enantioselective catalysts) that retain the majority of the backbone's structural features, yet at the same time incorporate subtle changes at its active site that depend on the structural characteristics of the regulation agent (RA) employed.
Journal ArticleDOI
Active biopolymers in green non-conventional media: a sustainable tool for developing clean chemical processes
Pedro Lozano,Juana M. Bernal,Susana Nieto,Celia Gomez,Eduardo García-Verdugo,Santiago V. Luis +5 more
TL;DR: By understanding structure-function relationships of biopolymers in ILs, as well as for ILs themselves, several integral green chemical processes of (bio)catalytic transformation and pure product separation are pointed out, and developments based on DNA/ILs systems are considered.
Journal ArticleDOI
Enantioselective access to chiral drugs by using asymmetric hydrogenation catalyzed by Rh(P-OP) complexes.
Journal ArticleDOI
RhI, IrIII ,and CoIII Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities
TL;DR: In this article, a streamlined synthesis of binaphthyl backbone Cpx ligands that feature new substituents at the 3,3′-positions was reported, namely trimethylsilyl, I, and Br. All ligands are smoothly complexed with rhodium(I) salts.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
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Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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The atom economy--a search for synthetic efficiency
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Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
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