Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines
TL;DR: An efficient, highly atom economic synthesis of hitherto unknown spirocyclic pyrazolidines in a one-pot process was developed and every position in the final product can be substituted which renders the method ideal for applications in combinatorial or medicinal chemistry.
Journal ArticleDOI
Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis
TL;DR: This review outlines the current status of flow chemocatalysis and bioc atalysis within the pharmaceutical landscape and the trends and challenges that these technologies face are highlighted, based on recently disclosed applications from industry and innovative solutions from academia.
Journal ArticleDOI
Transition metal-free, iodide-mediated domino carbonylation–benzylation of benzyl chlorides with arylboronic acids under ambient pressure of carbon monoxide
TL;DR: In this article, a conceptually distinct approach toward the synthesis of 1,2,3-triarylpropan-1-one by NaI-catalyzed domino carbonylation was developed under ambient pressure of CO gas.
Journal ArticleDOI
Stereoselective synthesis of N-heterocycles through amine addition to nitroalkenes
TL;DR: An efficient route for the preparation of substituted N-heterocycles was developed through the amine addition to nitroalkenes that tolerates a large substrate scope with good to excellent yields and excellent stereoselectivities.
References
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Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
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TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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The atom economy--a search for synthetic efficiency
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