Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Journal ArticleDOI
A substrate-driven approach to determine reactivities of α,β-unsaturated carboxylic esters towards asymmetric bioreduction.
Gábor Tasnádi,Christoph K. Winkler,Dorina Clay,Nargis Sultana,Walter M. F. Fabian,Mélanie Hall,Klaus Ditrich,Kurt Faber +7 more
TL;DR: The degree of C=C bond activation in the asymmetric bioreduction of α,β-unsaturated carboxylic esters by ene-reductases was studied, and general recommendations to render these "borderline-substrates" more reactive towards enzymatic reduction are proposed.
Journal ArticleDOI
Nickel-Catalyzed C–N Cross-Coupling of Ammonia, (Hetero)anilines, and Indoles with Activated (Hetero)aryl Chlorides Enabled by Ligand Design
TL;DR: The Ni(II) precatalyst (C1) featuring the phosphonite ancillary ligand Phen-DalPhos (L1) was employed in the cross-coupling of (hetero)anilines with hetero)aryl chlorides and in the diarylation of...
Journal ArticleDOI
Iridium(I) hydroxides : powerful synthons for bond activation
Byron J. Truscott,David J. Nelson,Cristina Lujan,Cristina Lujan,Alexandra M. Z. Slawin,Steven P. Nolan +5 more
TL;DR: A family of iridium(I) hydroxides of the form [Ir(cod)(NHC)(OH)] (cod = 1,5-cyclooctadiene, NHC = N-heterocyclic carbene) is reported, revealing a versatile and useful synthon capable of activating important chemical bonds under mild (typically room temperature) conditions.
Journal ArticleDOI
2-Methyltetrahydrofuran: A Green Solvent for Iron-Catalyzed Cross-Coupling Reactions
TL;DR: Iron-catalyzed cross-coupling of aryl chlorides and tosylates with challenging organometallic reagents possessing β-hydrogens is found to proceed in good to excellent yields with the green, sustainable, and eco-friendly 2-methyltetrahydrofuran (2-MeTHF) as solvent.
Journal ArticleDOI
Modular POP Ligands in Rhodium‐Mediated Asymmetric Hydrogenation: A Comparative Catalysis Study
TL;DR: In this article, a set of POP ligands have been developed to provide a straightforward access to enantiomerically enriched α-amino acid, carboxylic acid, amine, and alcohol derivatives that are valuable chiral building blocks.
References
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