Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
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Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt Precatalysts.
Lauren N. Mendelsohn,Calum MacNeil,Tyler P. Pabst,David K. Leahy,Ian W. Davies,Paul J. Chirik +5 more
TL;DR: The cobalt-catalyzed asymmetric hydrogenation of indazole-containing enamides relevant to the synthesis of the calcitonin gene-related peptide (CGRP) receptor antagonist, zavegepant (1), approved for the treatment of migraines, is described in this paper .
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Insertion reactions of isocyanides into the Metal-C(sp3) bonds of ylide complexes
María-Teresa Chicote,Isabel Saura-Llamas,María-Francisca García-Yuste,Delia Bautista,José Vicente +4 more
TL;DR: In this paper, the insertion reactions observed in the Pd-C bond of a P-ylide complex were reported, resulting from the insertion of the unsaturated molecule in one of their Pd−C bonds and the hydrogen transfer from the methine CH to the iminobenzoyl nitrogen.
Journal ArticleDOI
Enhanced Activity of Bulky N-Heterocylic Carbenes in Nickel–NHC Catalyzed Kumada–Corriu Cross-Coupling of Aryl Tosylates
TL;DR: The Ni catalysis has expanded the chemical reactivity of cross-coupling reactions and led to the discovery of catalytic systems that are now widely applied in the world as discussed by the authors .
Journal ArticleDOI
A general catalyst for Buchwald-Hartwig amination to prepare secondary five-membered heteroaryl amines with breaking the base barrier
TL;DR: In this paper , the authors proposed a protocol for the preparation of secondary five-membered heteroaryl amines via the palladium-catalyzed CN cross-coupling reaction.
Journal ArticleDOI
β-Amino Acid Organocatalysts in the Asymmetric Michael Addition of Isobutyraldehyde to N-Substituted Maleimides
TL;DR: Several unexpected and interesting structural effects of aliphatic and cycloaliphatic β-amino acids obtained in the enantioselective conjugate addition of isobutyraldehyde to N-benzylmaleimide are disclosed.
References
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