Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Journal ArticleDOI
Efficient methods for the synthesis of chiral 2-oxazolidinones as pharmaceutical building blocks.
TL;DR: In this paper , a review summarizes the coupling reactions of epoxides and isocyanates for the preparation of 2-oxazolidinones and a synthetic example of a commercially available pharmaceutical compound utilizing this method is also introduced.
Journal ArticleDOI
P-Stereogenic Ir-MaxPHOX: A Step toward Privileged Catalysts for Asymmetric Hydrogenation of Nonchelating Olefins
Maria Biosca,P. de la Cruz-Sánchez,Jorge Faiges,Jèssica Margalef,Ernest Salomó,Antoni Riera,Xavier Verdaguer,Joan Ferré,Feliu Maseras,Maria Besora,Oscar Pàmies,Montserrat Diéguez +11 more
TL;DR: The IrMaxPHOX-type catalysts demonstrated high catalytic performance in the hydrogenation of a wide range of nonchelating olefins with different geometries, substitution patterns, and degrees of functionalization as discussed by the authors .
Journal ArticleDOI
Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE.
Юлдашев Шохжахон Аброрович,Joseph P. Smith,Nicole M. Ralbovsky,Юлдашев Шохжахон Аброрович,Mackenzie L. Lauro,Erik Hoyt,Erik D. Guetschow,Fengqiang Wang,John A. McIntosh,Zhijian Liu,Ian Mangion,Narayan Variankaval,Xiaodong Bu +12 more
TL;DR: In this paper, the authors proposed a methodology for residual protein detection, quantitation, and size-based speciation in the presence of small molecule APIs, with potential for wide applicability across industry for biocatalysis or directed enzyme evolution efforts within process development.
Journal ArticleDOI
Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE
TL;DR: In this article , the authors proposed a methodology for residual protein detection, quantitation, and size-based speciation in the presence of small molecule APIs, with potential for wide applicability across industry for biocatalysis or directed enzyme evolution efforts within process development.
Journal ArticleDOI
Understanding the synergistic effects observed when using tethered dual catalysts for heat and light activated catalysis
Danfeng Wang,Indrek Pernik,Indrek Pernik,Sinead T. Keaveney,Barbara A. Messerle,Barbara A. Messerle +5 more
TL;DR: In this article, a series of Ir(I) based complexes tethered to a BODIPY type photocatalyst through different tethering modes were investigated and it was found that the tethered dual catalysts were more effective at promoting heat activated intermolecular hydroamination than the un-tethered analogues.
References
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Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
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The atom economy--a search for synthetic efficiency
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