Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
More filters
Journal ArticleDOI
Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution
Olga V. Zatolochnaya,Sonia Rodriguez,Yongda Zhang,Kendricks S. Lao,Sergei Tcyrulnikov,Guisheng Li,Xiao-Jun Wang,Bo Qu,Soumik Biswas,Hari P. R. Mangunuru,Daniel Rivalti,Joshua D. Sieber,Jean-Nicolas Desrosiers,Joyce C. Leung,Nelu Grinberg,Heewon Lee,Nizar Haddad,Nathan K. Yee,Jinhua J. Song,Marisa C. Kozlowski,Chris H. Senanayake +20 more
TL;DR: A new class of tunable heterophosphole dimeric ligands have been designed and synthesized and described in a number of publications.
Journal ArticleDOI
A Glimpse into Green Chemistry Practices in the Pharmaceutical Industry
TL;DR: In this mini-review, the importance and implementation of green chemistry practices in the pharmaceutical industry are illustrated and a brief comparison between traditional unsustainable methods and modern green methods is made to shed light on the economic and environmental benefits of greener methods.
Journal ArticleDOI
Evaluating 1,1′-Bis(phosphino)ferrocene Ancillary Ligand Variants in the Nickel-Catalyzed C–N Cross-Coupling of (Hetero)aryl Chlorides
TL;DR: In this paper, a series of 10 structurally varied 1,1′-bis(bis(alkyl/aryl)phosphino)ferrocene ancillary ligands (LX) were systematically examined in selected competitive test cross-couplings of (hetero)aryl halides with furfurylamine, morpholine, and indole employing Ni(COD)2/LX catalyst mixtures.
Journal ArticleDOI
New Ruthenium(II) Indenylidene Complexes Bearing Unsymmetrical N-Heterocyclic Carbenes
Osman Ablialimov,Mariusz Kędziorek,Christian Torborg,Maura Malinska,Krzysztof Woźniak,Karol Grela +5 more
TL;DR: In this article, robust and air-stable ruthenium(II) indenylidene second-generation precatalysts with unsymmetrical N-heterocyclic carbene (NHC) ligands were synthesized.
Journal ArticleDOI
Homochiral metal–organic frameworks as heterogeneous catalysts
TL;DR: In this article, a mini-review of the structural design and catalytic performance of homochiral metal-organic frameworks (HMOFs) is presented, focusing on the relevance of the chemical reactions tested.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Related Papers (5)
Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.
Javier Magano,Joshua R. Dunetz +1 more