Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
More filters
Journal ArticleDOI
Organocatalytic aryl-aryl bond formation: An atroposelective [3,3]-rearrangement approach to BINAM derivatives
TL;DR: Density functional calculations reveal that, in the transition state for C-C bond formation, the phosphoric acid proton of the catalyst is fully transferred to one of the N-atoms of the substrate, and the resulting phosphate acts as a chiral counterion.
Journal ArticleDOI
Iron-Catalyzed Cross-Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability.
TL;DR: The strategic benefits of using iron catalysts as green and sustainable alternatives to precious metals in cross-coupling applications for the synthesis of pharmaceuticals are critically discussed.
Journal ArticleDOI
A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis
TL;DR: In this paper, the authors highlight a number of important considerations for the design of new and improved sustainable metal-catalyzed transformations in order to facilitate rapid adoption by the pharmaceutical industry.
Journal ArticleDOI
Palladium-catalyzed C(sp3)-H arylation of diarylmethanes at room temperature: synthesis of triarylmethanes via deprotonative-cross-coupling processes.
TL;DR: The first general, high-yielding, and scalable method for palladium-catalyzed C(sp(3))-H arylation of simple diarylmethane derivatives with aryl bromides at room temperature is reported, which facilitates access to a variety of sterically and electronically diverse hetero- and nonheteroaryl-containing triarylmethanes.
Journal ArticleDOI
The mechanism of enantioselective ketone reduction with Noyori and Noyori-Ikariya bifunctional catalysts.
Pavel A. Dub,John C. Gordon +1 more
TL;DR: Analysis presented herein expands the concept of "metal-ligand cooperation", redefines the term "cooperative ligand" and introduces "H(-)/H(+) outer-sphere hydrogenation" as a novel paradigm in outer- Spheres hydrogenation.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Related Papers (5)
Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.
Javier Magano,Joshua R. Dunetz +1 more