Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations
Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide
TL;DR: In this paper, the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations for Pd-catalyzed amination reactions is discussed.
Journal ArticleDOI
Principles and applications of halogen bonding in medicinal chemistry and chemical biology.
TL;DR: The theoretical background defining its strength and directionality, a systematic analysis of its occurrence and interaction geometries in protein-ligand complexes, and recent examples where halogen bonding has been successfully harnessed for lead identification and optimization are provided.
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Supramolecular Luminescent Sensors
TL;DR: Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores.
Journal ArticleDOI
Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry.
TL;DR: Palladium-catalyzed reactions involving isocyanide insertion offer a vast potential for the synthesis of nitrogen-containing fine chemicals and the achievements in this emerging field are discussed.
References
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Journal ArticleDOI
Studies on 4-Hydroxycoumarins. V. The Condensation of α,β-Unsaturated Ketones with 4-Hydroxycoumarin1
Journal ArticleDOI
Efficient Monophosphorus Ligands for Palladium-Catalyzed Miyaura Borylation
Wenjun Tang,Santosh Keshipeddy,Yongda Zhang,Xudong Wei,Jolaine Savoie,Nitinchandra D. Patel,Nathan K. Yee,Chris H. Senanayake +7 more
TL;DR: In combination with the Bedford Pd precursor, the new biaryl monophosphorus ligand 5 was efficient for palladium-catalyzed Miyaura borylation of sterically hindered aryl bromides at low catalyst loadings.
Journal ArticleDOI
Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.
Anne-Marie Faucher,Murray D. Bailey,Pierre L. Beaulieu,Christian Brochu,Jean-Simon Duceppe,Jean-Marie Ferland,Ghiro Elise,Vida Gorys,Ted Halmos,Stephen H. Kawai,Martin Poirier,Bruno Simoneau,Youla S. Tsantrizos,Montse Llinas-Brunet +13 more
TL;DR: The synthesis of BILN 2061, an NS3 protease inhibitor with proven antiviral effect in humans, was accomplished in a convergent manner from four building blocks in a suitable manner for preclinical pharmacological evaluation.
Journal ArticleDOI
Packed‐Bed Reactors for Continuous‐Flow C ? N Cross‐Coupling
Journal ArticleDOI
Asymmetric catalysis by chiral rhodium complexes in hydrogenation and hydrosilylation reactions
TL;DR: In this article, a supported chiral catalyst was used to improve the usefulness of asymmetric catalysis, starting from a Merrifield resin, which was used both in reduction and in hydrosilylation.
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