Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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A novel α-L-Rhamnosidase renders efficient and clean production of icaritin
Leiyu Cheng,Han Zhang,Hai-Bin Cui,Jin-xing Cheng,Wenya Wang,Bin Wei,Fang Liu,Hao Liang,Xiaolin Shen,Qipeng Yuan +9 more
TL;DR: In this paper , a new α-L-rhamnosidase (Rhase-I) was discovered from Talaromyces stollii CLY-6, which can efficiently cleave both the outer and inner rhamnose bonds of epimedin C.
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Further Optimization of a Scalable Biocatalytic Route to (3R)-N-Boc-3-aminoazepane with Immobilized ω-Transaminase
Feng Yahui,Zhongqing Wang,Zhonghua Luo,Chen Minghong,Fang He,Liu Bin,Siegfried Goldmann,Lei Zhang +7 more
TL;DR: In this article, an efficient method for the synthesis of (3R)-N-Boc-3-aminoazepane with immobilized ω-transaminase (ω-TA) was further optimized.
Journal ArticleDOI
1,1-Diamino-2-nitroethylenes as excellent hydrogen bond donor organocatalysts in the Michael addition of carbon-based nucleophiles to β-nitrostyrenes
R. Silva,Gustavo P. da Silva,Diego P. Sangi,Diego P. Sangi,João Guilherme de Moraes Pontes,Antonio G. Ferreira,Arlene G. Corrêa,Márcio W. Paixão +7 more
TL;DR: In this article, a new class of hydrogen bond donor catalysts based on the 1,1-diamino-2-nitroethylene scaffold has been introduced for the activation of trans-β-nitrostyrenes toward reactions with a range of carbon-based nucleophiles, affording the corresponding adducts in excellent yields.
Journal ArticleDOI
New chiral diphosphoramidite rhodium(I) complexes for asymmetric hydrogenation
TL;DR: Chiral 1,5-cyclooctadiene rhodium(I) cationic complexes with C2-symmetric chelate diphosphoramidite ligands containing (R,R)-1,2-diaminocyclohexane as the backbone and two atropoisomeric biaryl units were easily synthesized and fully characterized by multinuclear one- and two-dimensional NMR spectroscopy and elemental analysis.
Journal ArticleDOI
Bioinspired Palladium Nanoparticles Supported on Soil-Derived Humic Acid Coated Iron-Oxide Nanoparticles as Catalyst for C–C Cross-Coupling and Reduction Reactions
TL;DR: Pd nanoparticles supported on humic acid-coated nanoferrites as magnetically-recoverable catalyst was expediently prepared from inexpensive precursors and characterized by techniques such as SEM, TEM, XPS, FT-IR, XRD, ICP-AES, EDX as discussed by the authors.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
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