The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation.
Fan Yang,Xinxian Deng,Wenxiu Ma,Joel B. Berletch,Natalia A. Rabaia,Gengze Wei,James M. Moore,Galina N. Filippova,Jun Xu,Yajuan Liu,William Stafford Noble,Jay Shendure,Christine M. Disteche +12 more
TLDR
The X-linked lncRNA Firre helps to position the inactive X chromosome near the nucleolus and to preserve one of its main epigenetic features, H3K27me3, demonstrating a role in maintenance of an important epigenetic feature of the inactiveX chromosome.Abstract:
Background
In mammals, X chromosome genes are present in one copy in males and two in females. To balance the dosage of X-linked gene expression between the sexes, one of the X chromosomes in females is silenced. X inactivation is initiated by upregulation of the lncRNA (long non-coding RNA) Xist and recruitment of specific chromatin modifiers. The inactivated X chromosome becomes heterochromatic and visits a specific nuclear compartment adjacent to the nucleolus.read more
Citations
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