The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score
TLDR
The profile of the PDQ-39 should be of value in studies aimed at determining the impact of treatment regimes upon particular aspects of functioning and well-being in patients with Parkinson's disease, while the PDSI will provide a summary score ofThe impact of the illness on functioning andWell-being and will be of use in the evaluation of the overall effect of different treatments.Abstract:
Objectives: to briefly outline the development and validation of the Parkinson's Disease Questionnaire (PDQ-39) and then to provide evidence for the use of the measure as either a profile of health status scores or a single index figure. Design: the PDQ-39 was administered in two surveys: a postal survey of patients registered with local branches of the Parkinson's Disease Society of Great Britain (n = 405) and a survey of patients attending neurology clinics for treatment for Parkinson's disease (n = 146). Data from the eight dimensions of the PDQ-39 were factor-analysed. This produced a single factor on the data from both surveys. Outcome measures: the eight dimensions of the PDQ-39 and the new single index score—the Parkinson's disease summary index (PDSI), together with clinical assessments (the Columbia rating scale and the Hoehn and Yahr staging score). Results: in the postal survey 227 patients returned questionnaires (58.2%). All 146 patients approached in the clinic sample agreed to take part. Higher-order principal-components factor analysis was undertaken on the eight dimensions of the PDQ-39 and produced one factor on both datasets. Consequently it was decided that the scores of the eight domains could be summed to produce a single index figure. The psychometric properties of this index were explored using reliability tests and tests of construct validity. The newly derived single index was found to be both internally reliable and valid. Discussion: data from the PDQ-39 can be presented either in profile form or as a single index figure. The profile should be of value in studies aimed at determining the impact of treatment regimes upon particular aspects of functioning and well-being in patients with Parkinson's disease, while the PDSI will provide a summary score of the impact of the illness on functioning and well-being and will be of use in the evaluation of the overall effect of different treatments. Furthermore, the PDSI reduces the number of statistical comparisons and hence the role of chance when exploring data from the PDQ-39.read more
Citations
More filters
Journal ArticleDOI
Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations.
Christopher G. Goetz,Werner Poewe,Olivier Rascol,Cristina Sampaio,Glenn T. Stebbins,Carl Counsell,Nir Giladi,Robert G. Holloway,Charity G. Moore,Gregor K. Wenning,Melvin D. Yahr,Lisa Seidl +11 more
TL;DR: The Movement Disorder Society Task Force for Rating Scales for Parkinson's disease (PD) prepared a critique of the Hoehn and Yahr scale, which recommends that it be used in its original form for demographic presentation of patient groups and in research settings, the HY scale is useful primarily for defining inclusion/exclusion criteria.
Journal ArticleDOI
What contributes to quality of life in patients with Parkinson's disease?
TL;DR: Depression, disability, postural instability, and cognitive impairment have the greatest influence on QoL in Parkinson's disease, and the improvement of these features should become an important target in the treatment of the disease.
Journal ArticleDOI
Deep brain stimulation.
TL;DR: Deep brain stimulation is clinically effective in improving motor function of essential tremor, Parkinson's disease and primary dystonia and in relieving obsessive-compulsive disorder.
Journal ArticleDOI
The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease.
Pablo Martinez-Martin,Carmen Rodriguez-Blazquez,Monica M. Kurtis,K. Ray Chaudhuri,K. Ray Chaudhuri +4 more
TL;DR: The Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients.
Journal ArticleDOI
The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study
TL;DR: The pattern of cognitive deficits seen among patients using the Mini-Mental State Examination, a pattern recognition task, and the Tower of London task suggests that sub-groups of patients based on cognitive ability might be identifiable even in the early stages of disease, which may reflect regional differences in the underlying neuropathological processes.
References
More filters
Journal ArticleDOI
Parkinsonism: Onset, progression, and mortality
Margaret M. Hoehn,Melvin D. Yahr +1 more
TL;DR: Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
Journal Article
Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study
John E. Ware,Mark Kosinski,Martha S. Bayliss,Colleen A. McHorney,William H. Rogers,Anastasia E. Raczek +5 more
TL;DR: Results suggest that the two summary measures may be useful in most studies and that their empiric validity, relative to the best SF-36 scale, will depend on the application.
Journal ArticleDOI
The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease.
TL;DR: A short 39 item Parkinson's Disease Questionnaire, referred to here as the PDQ-39, proved to have satisfactory internal and test-retest reliability, and construct validity in relation to other measures, reported by respondents with Parkinson's disease.
Journal ArticleDOI
Standards for validating health measures: Definition and content
TL;DR: The dimensionality of health and the range of health states that can be measured within each dimension are discussed and it is recommended that labels be assigned to health measures in a manner consistent with their content and other evidence of validity.
Journal ArticleDOI
Quality of life in patients with Parkinson's disease: development of a questionnaire.
TL;DR: The PDQL is a relevant, reliable, and valid measure of the quality of life of patients with Parkinson's disease and correlated highly with the corresponding scales of the standard quality oflife indices.
Related Papers (5)
Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.
Christopher G. Goetz,Barbara C. Tilley,Stephanie R. Shaftman,Glenn T. Stebbins,Stanley Fahn,Pablo Martinez-Martin,Werner Poewe,Cristina Sampaio,Matthew B. Stern,Richard Dodel,Bruno Dubois,Robert G. Holloway,Joseph Jankovic,Jaime Kulisevsky,Anthony E. Lang,Andrew J. Lees,Sue Leurgans,Peter A. LeWitt,David L. Nyenhuis,C. Warren Olanow,Olivier Rascol,Anette Schrag,Jeanne A. Teresi,Jacobus J. van Hilten,Nancy R. LaPelle,Pinky Agarwal,Saima Athar,Yvette Bordelan,Helen Bronte-Stewart,Richard Camicioli,Kelvin L. Chou,Wendy Cole,Arif Dalvi,Holly Delgado,Alan Diamond,Jeremy P.R. Dick,John E. Duda,Rodger J. Elble,Carol Evans,V. G. H. Evidente,Hubert H. Fernandez,Susan H. Fox,Joseph H. Friedman,Robin D. Fross,David A. Gallagher,Deborah A. Hall,Neal Hermanowicz,Vanessa K. Hinson,Stacy Horn,Howard I. Hurtig,Un Jung Kang,Galit Kleiner-Fisman,Olga Klepitskaya,Katie Kompoliti,Eugene C. Lai,Maureen L. Leehey,Iracema Leroi,Kelly E. Lyons,Terry McClain,Steven W. Metzer,Janis M. Miyasaki,John C. Morgan,Martha Nance,Joanne Nemeth,Rajesh Pahwa,Sotirios A. Parashos,Jay S. Schneider,Kapil D. Sethi,Lisa M. Shulman,Andrew Siderowf,Monty Silverdale,Tanya Simuni,Mark Stacy,Robert Malcolm Stewart,Kelly L. Sullivan,David M. Swope,Pettaruse M. Wadia,Richard Walker,Ruth H. Walker,William J. Weiner,Jill Wiener,Jayne R. Wilkinson,Joanna M. Wojcieszek,Summer C. Wolfrath,Frederick Wooten,Allen Wu,Theresa A. Zesiewicz,Richard M. Zweig +87 more