Journal ArticleDOI
The prevalence of genetic and serologic markers in an unselected European population‐based cohort of IBD patients
Lene Riis,Ida Vind,Severine Vermeire,Frank Wolters,K.H. Katsanos,P. Politi,Joao Freitas,Ioannis A. Mouzas,Colm O'Morain,Victor Ruiz‐Ochoa,Selwyn Odes,Vibeke Binder,Pia Munkholm,Bjørn Moum,Reinhold W. Stockbrügger,Ebbe Langholz +15 more
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The prevalence of mutations in CARD15 varied across Europe, and was not correlated to the incidence of CD, and there was no association between mutations in TLR4 and IBD.Abstract:
Background and Aim: The aetiology of inflammatory bowel disease (IBD) is unknown, but it has become evident that genetic factors are involved in disease susceptibility. Studies have suggested a north–south gradient in the incidence of IBD, raising the question whether this difference is caused by genetic heterogeneity. We aimed to investigate the prevalence of polymorphisms in CARD15 and TLR4 and occurrence of anti-Saccharomyces cerevisiae (ASCA) and antineutrophil cytoplasmic antibodies (pANCA) in a European population-based IBD cohort. Methods: Individuals from the incident cohort were genotyped for three mutations in CARD15 and the Asp299gly mutation in TLR4. Levels of ASCA and pANCA were assessed. Disease location and behaviour at time of diagnosis was obtained from patient files. Results: Overall CARD15 mutation rate was 23.9% for CD and 9.6% for UC patients (P 0.001). Mutations were less present in the Scandinavian countries (12.1%) versus the rest of Europe (32.8%) (P 0.001). Overall population attributable risk was 11.2%. TLR4 mutation rate was 7.6% in CD, 6.7% in UC patients and 12.3% in healthy controls (HC), highest among South European CD patients and HC. ASCA was seen in 28.5% of CD patients with no north–south difference, and was associated with complicated disease. pANCA was most common in North European UC patients and not associated with disease phenotype. Conclusion: The prevalence of mutations in CARD15 varied across Europe, and was not correlated to the incidence of CD. There was no association between mutations in TLR4 and IBD. The prevalence of ASCA was relatively low; however related to severe CD. (Inflamm Bowel Dis 2007;13:24 –32)read more
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Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
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Second European Evidence-Based Consensus on the Diagnosis and Management of Ulcerative Colitis Part 1: Definitions and Diagnosis
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TL;DR: The aim of the Consensus is to promote a European perspective on the management of ulcerative colitis and its dilemmas to avoid duplication of effort in the future.
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European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
Eduard F. Stange,Simon Travis,Severine Vermeire,Walter Reinisch,K. Geboes,A. Barakauskiene,R. Feakins,Jean-François Fléjou,Hans H Herfarth,Daan W. Hommes,Limas Kupčinskas,Peter L. Lakatos,Gerassimos J. Mantzaris,Stefan Schreiber,Vincenzo Villanacci,Bryan F. Warren +15 more
TL;DR: The aim of the Consensus is to promote a European perspective on the management of ulcerative colitis (UC) and its dilemmas and to avoid duplication of effort in the future.
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Diagnostics of Inflammatory Bowel Disease
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Intestinal barrier in inflammatory bowel disease.
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References
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
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The history and geography of human genes
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Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
TL;DR: Differences in incidence across age, time, and geographic region suggest that environmental factors significantly modify the expression of Crohn's disease and ulcerative colitis.
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Epidemiology in Medicine
TL;DR: The core of the subject remains essentially simple, and a good epidemiological study should be capable of describing in such a way that all who are interested in the cause of disease can follow the argument and decide for themselves the validity of the conclusions as mentioned in this paper.
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The history and geography of human genes
TL;DR: The author examines the history of human evolution in Africa, Europe, and Asia through the lens of genetic, archaeological, and linguistic information.
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