The Role of Galectins as Modulators of Metabolism and Inflammation.
TLDR
Information on galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation and the potential to target galectins for therapeutic purposes is presented.Abstract:
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.read more
Citations
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The intestinal milieu influences the immunoproteome of male and female Heligmosomoides polygyrus bakeri L4 stage.
Marta Maruszewska-Cheruiyot,Katarzyna Donskow-Łysoniewska,Katarzyna Krawczak,Ludmiła Szewczak,Ewa Joachimiak,Maria Doligalska +5 more
TL;DR: The gastrointestinal nematode Heligmosomoides polygyrus bakeri shows enhanced survival in mice with colitis and gives new insights into helminth therapy as well as host–parasite interactions.
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Bruceine A protects against diabetic kidney disease via inhibiting galectin-1.
Huiying Li,Xiao li Zhao,Liyun Zheng,Xiukun Wang,Shuai Lin,Jia-jia Shen,Hangjiang Ren,Yi Bin Li,Qiang Qiu,Zhen Wang +9 more
TL;DR: In this paper , the authors identified Bruceine A as a kidney protective molecule against a model of diabetic kidney disease in db/db mice with potent anti-inflammatory activity both in vitro and in vivo.
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Intra-individual reproducibility of galectin-1, haptoglobin, and nesfatin-1 as promising new biomarkers of immunometabolism.
Matthew Schenk,Robin Reichmann,Liselot Koelman,Andreas Pfeiffer,Natalia Rudovich,Krasimira Aleksandrova +5 more
TL;DR: Assay measurements of galectin-1, haptoglobin, and nesfatin-1 showed good to excellent within-subject reproducibility over a 4-month period, indicating that they may serve as feasible and reliable biomarkers for assessing metabolic inflammation in population research.
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Лектини: отримання, властивості, застосування у біології та медицині
TL;DR: The aim of the work is to select and analyze the results of works on the extraction of lectins, the study of their properties and application in biology and medicine, and the combination of properties of Lectins and magnetically sensitive iron-containing nanocomposites in the composition of magnetic fluids for use in oncology is considered relevant and promising.
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The effect of pre-slaughter starvation on muscle protein degradation in sea bream (Sparus aurata): formation of ACE inhibitory peptides and increased digestibility of fillet
Giovanna Lippe,Barbara Prandi,Tiziana Bongiorno,Francesca Mancuso,Emilio Tibaldi,Andrea Faccini,Stefano Sforza,Mara Lucia Stecchini +7 more
TL;DR: Pre-slaughter starvation, other than decreases the environmental impact of fish aquaculture, is an effective tool in obtaining good-quality sea bream fillets that provide potential health benefits for hypertensive and GERD consumers.
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