The Role of Galectins as Modulators of Metabolism and Inflammation.
TLDR
Information on galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation and the potential to target galectins for therapeutic purposes is presented.Abstract:
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.read more
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References
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Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats
TL;DR: Knockdown of GAL1-encoding gene (Lgals1) attenuated adipogenesis and lipogenesis in both 3T3-L1 and HIB1B adipocytes and has an essential role in HFD-induced obesity development.
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Immunomodulatory effects of galectin-1 on an IgE-mediated allergic conjunctivitis model.
Claudia Bosnic Mello,Lisandra Ramos,Alexandre Dantas Gimenes,Teresa Raquel de Moraes Andrade,Sonia Maria Oliani,Cristiane Damas Gil +5 more
TL;DR: Recombinant Gal-1 has an important role in ocular allergic inflammation and represents a potential target for the development of new therapeutic strategies in eye diseases.
Journal ArticleDOI
Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
Julieta Carabelli,Valeria Quattrocchi,Alejandra D'Antuono,Patricia Ines Zamorano,María Virginia Tribulatti,Oscar Campetella +5 more
TL;DR: Findings argue in favor of the use of Gal‐8 as an immune‐stimulator molecule to enhance the adaptive immune response.
Journal ArticleDOI
Overexpression of galectin-7 in mouse epidermis leads to loss of cell junctions and defective skin repair.
Gaëlle Gendronneau,Sadaf Sanii,Tien Dang,Frédérique Deshayes,Delphine Delacour,Evelyne Pichard,Tamara Advedissian,Sukhvinder S. Sidhu,Mireille Viguier,Thierry Magnaldo,Françoise Poirier +10 more
TL;DR: It is concluded that a critical level of this protein is required for maintaining proper epidermal homeostasis, as results indicate that an excess of galectin-7 leads to a destabilisation of adherens junctions associated with defects in epidermis repair.
Journal ArticleDOI
Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC)
Rani Fritz,Hamid Reza Kohan-Ghadr,Jay M. Bolnick,Alan D. Bolnick,Brian A. Kilburn,Michael P. Diamond,Sascha Drewlo,D. Randall Armant,D. Randall Armant +8 more
TL;DR: In this pilot study, EVT cells isolated by TRIC early in gestation exhibited altered protein expression patterns before an EPL compared with uncomplicated term pregnancies.