The Role of Galectins as Modulators of Metabolism and Inflammation.
TLDR
Information on galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation and the potential to target galectins for therapeutic purposes is presented.Abstract:
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.read more
Citations
More filters
Journal ArticleDOI
Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities
Ignacio M. Seropian,Germán González,Sebastian Matias Maller,Daniel Berrocal,Antonio Abbate,Gabriel A. Rabinovich,Gabriel A. Rabinovich +6 more
TL;DR: The emerging roles of Gal-1 in cardiovascular diseases including acute myocardial infarction, heart failure, Chagas cardiomyopathy, pulmonary hypertension, and ischemic stroke are discussed, highlighting underlying anti-inflammatory mechanisms and therapeutic opportunities.
Journal ArticleDOI
Structural characterization of the N-linked glycans in the receptor binding domain of the SARS-CoV-2 spike protein and their interactions with human lectins using NMR spectroscopy.
Maria Pia Lenza,Iker Oyenarte,Tammo Diercks,Jon I. Quintana,Ana Gimeno,Alexandre Bosch,Helena Coelho,Ana Diniz,Francesca Peccati,Sandra Delgado,Mikel Valle,Oscar Millet,Nicola G. A. Abrescia,Asis Palazon,Filipa Marcelo,Gonzalo Jiménez-Osés,Jesús Jiménez-Barbero,Ana Ardá,June Ereño-Orbea +18 more
TL;DR: 3D models of the interacting complexes have been proposed based on the analysis of glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells by using NMR.
Journal ArticleDOI
Targeting Galectins With Glycomimetics.
Sara Bertuzzi,Jon I. Quintana,Ana Ardá,Ana Gimeno,Jesús Jiménez-Barbero,Jesús Jiménez-Barbero +5 more
TL;DR: The last approaches toward the specific design of glycomimetics as potential drugs against galectins are gathered, from the employment of S-glycosyl compounds to peptidomimetics and multivalent glycopolymers, mostly employed to recognize and/or detect hGal-1 and h Gal-3.
Journal ArticleDOI
Roles of galectin-3 in metabolic disorders and tumor cell metabolism.
TL;DR: A brief review summarizes the current understanding of the roles and actions of galectin-3 in these metabolic diseases and in tumor metabolism.
Journal ArticleDOI
UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract
Abdelsamed I. Elshamy,Abdel Razik H. Farrag,Iriny M. Ayoub,Karam A Mahdy,Rehab F. Taher,Abd El-Nasser G Ei Gendy,Tarik A. Mohamed,Salim S. Al-Rejaie,Yasser A Ei-Amier,Ahmed M Abd-EIGawad,Ahmed M Abd-EIGawad,Mohamed A. Farag,Mohamed A. Farag +12 more
TL;DR: It could be concluded that C. conglomeratus extract provides significant gastroprotective activity in ethanol-induced gastric ulcer and ought to be included in nutraceuticals in the future for ulcer treatment.
References
More filters
Journal ArticleDOI
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Apoptosis of T cells mediated by galectin-1
TL;DR: Galectin-1 induced apoptosis of activated human T cells and human T leukaemia cell lines and represents a new mechanism for regulating the immune response.
Journal ArticleDOI
Galectin-3: an open-ended story.
TL;DR: Through specific interactions with a variety of intra- and extracellular proteins galectin-3 affects numerous biological processes and seems to be involved in different physiological and pathophysiological conditions, such as development, immune reactions, and neoplastic transformation and metastasis.
Journal ArticleDOI
Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
Louise A. Koopman,Hernan D. Kopcow,Basya Rybalov,Jonathan E. Boyson,Jordan S. Orange,Frederick Schatz,Rachel Masch,Charles J. Lockwood,Asher D. Schachter,Peter J. Park,Jack L. Strominger +10 more
TL;DR: Natural killer cells constitute 50–90% of lymphocytes in human uterine decidua in early pregnancy and are compared with the CD56bright and CD56dim peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR.
Journal ArticleDOI
Protein glycation, diabetes, and aging.
Peter C. Ulrich,Anthony Cerami +1 more
TL;DR: A new class of agents, exemplified by 4,5-dimethyl-3-phenacylthiazolium chloride (DPTC), which can chemically break already-formed AGE protein-protein crosslinks, are developed, based on a new theory of AGE crosslinking that postulates that alpha-dicarbonyl structures are present in AGEprotein- protein crosslinks.