The Role of Galectins as Modulators of Metabolism and Inflammation.
TLDR
Information on galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation and the potential to target galectins for therapeutic purposes is presented.Abstract:
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.read more
Citations
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Journal ArticleDOI
Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection.
Adriano Bertelli,Liliana Maria Sanmarco,Carla Antonela Pascuale,Miriam Postan,Maria del Pilar Aoki,María Susana Leguizamón +5 more
TL;DR: The results support that Gal-8 exerts an anti-inflammatory role in chronic T. cruzi infection by observing a generalized increase in heart, skeletal muscle, and liver inflammation associated with extensive fibrosis, unrelated to tissue parasite loads.
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Tear Cocktail: Composition of Tears
TL;DR: This chapter covers most of the tear constituents that have been investigated so far, covering proteins and lipids, vitamins, trace elements, etc.
Journal ArticleDOI
Structural, molecular, functional and immunological characterization of Wuchereria bancrofti-galectin.
Nazeer Yasin,Hoti Sugerappa Laxmanappa,Uday M. Muddapur,Jennifer Cheruvathur,S.M. Udaya Prakash,Hirekodathakallu V. Thulasiram +5 more
TL;DR: Study of the galectin of lymphatic filarial parasite Wb-Gal shows that it is a member of the lectin family of proteins binding to different carbohydrates and may have an important role in the pathophysiology of filarial infection which needs to be investigated in greater detail.
Journal ArticleDOI
Characterization and expression of galectin-3 in grass carp (Ctenopharyngodon idella).
Denghui Zhu,Rong Huang,Pengfei Chu,Liangming Chen,Yangyu Li,Libo He,Yongming Li,Lanjie Liao,Zuoyan Zhu,Yaping Wang +9 more
TL;DR: The expression of CiGal3 in liver and spleen was induced post grass carp reovirus, lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly I:C) challenge, suggesting that CiGal 3 plays a vital role in the immune system.
Journal ArticleDOI
Galectins as potential pharmacological targets in renal injuries of diverse etiology
TL;DR: The present review discusses the role of different galectins in renal diseases of diverse etiology, and galectin-1, 8, and 9 impart renoprotective effects as per clinical and preclinical studies, respectively.
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