The Role of Galectins as Modulators of Metabolism and Inflammation.
TLDR
Information on galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation and the potential to target galectins for therapeutic purposes is presented.Abstract:
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.read more
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References
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Journal ArticleDOI
Galectin-7 in the Control of Epidermal Homeostasis after Injury
Gaëlle Gendronneau,Sukhvinder S. Sidhu,Delphine Delacour,Tien Dang,Chloé Calonne,Denis Houzelstein,Thierry Magnaldo,Françoise Poirier +7 more
TL;DR: The generation of galectin-7-deficient mice that are viable and do not display phenotypical abnormalities in skin structure or expression of epidermal markers are reported, providing the first genetic evidence showing that galectins can modulate keratinocyte apoptosis, proliferation, and migration during skin repair.
Journal ArticleDOI
Phosphorylation of the β-Galactoside-binding Protein Galectin-3 Modulates Binding to Its Ligands
TL;DR: The process by which phosphorylation modulates protein-carbohydrate interactions has important implications for understanding the biological functions of this protein, and may serve as an “on/off” switch for its sugar binding capabilities.
Journal ArticleDOI
Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans
S. de Kivit,Eirikur Saeland,Aletta D. Kraneveld,H. J. G. van de Kant,Bastiaan Schouten,B.C.A.M. van Esch,Jan Knol,Aline B. Sprikkelman,L. B. van der Aa,Léon M.J. Knippels,Johan Garssen,Y. (Yvette) van Kooyk,Linette E M Willemsen +12 more
TL;DR: The involvement of galectin‐9 as a mechanism by which scGOS/lcFOS in combination with Bifidobacterium breve M‐16V protects against acute allergic symptoms was investigated.
Journal ArticleDOI
Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to a distinct crystalloid-free granule population in mature human eosinophils
TL;DR: The ultrastructural immunogold localization of CLC protein (lysophospholipase) to a large, crystalloid-free granule in mature circulating eosinophils supports the persistence of a distinct "primary" granule population that serves as a major intracytoplasmic repository for this enzyme.
Journal ArticleDOI
Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity.
Kikuko Hotta,Tohru Funahashi,Yuko Matsukawa,Masahiko Takahashi,Hitoshi Nishizawa,Ken Kishida,Morihiro Matsuda,Hiroshi Kuriyama,Shinji Kihara,Tadashi Nakamura,Yoshihiro Tochino,Noni L. Bodkin,Barbara C. Hansen,Yuji Matsuzawa +13 more
TL;DR: Induction of galectin-12 expression by the thiazolidinedione, troglitazone, was paralleled by an increase in the number of apoptotic cells in adipose tissue and results suggest that galectIn-12, an adipose-expressed galECTin-like molecule, may participate in the apoptosis of adipocytes.