Galectins at a glance.
TLDR
Recent literature on the many cellular activities that have been ascribed to galectins are summarized, including carbohydrate-independent interactions with cytosolic or nuclear targets and carbohydrate-dependent interactions with extracellular glycoconjugates.Abstract:
Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease. How such a small family of only 15 members can have such widespread effects remains a conundrum. In this Cell Science at a Glance article, we summarise recent literature on the many cellular activities that have been ascribed to galectins. As shown on the accompanying poster, these include carbohydrate-independent interactions with cytosolic or nuclear targets and carbohydrate-dependent interactions with extracellular glycoconjugates. We discuss how these intra- and extracellular activities might be linked and point out the importance of unravelling molecular mechanisms of galectin function to gain a true understanding of their contributions to the physiology of the cell. We close with a short outlook on the organismal functions of galectins and a perspective on the major challenges in the field.read more
Citations
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Glycosylation in health and disease.
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The Use of Chitosan, Alginate, and Pectin in the Biomedical and Food Sector-Biocompatibility, Bioadhesiveness, and Biodegradability.
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Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Jingyue Jia,Aurore Claude-Taupin,Yuexi Gu,Seong Won Choi,Ryan Peters,Bhawana Bissa,Michal H. Mudd,Lee Allers,Sandeep Pallikkuth,Keith A. Lidke,Michelle Salemi,Brett S. Phinney,Muriel Mari,Fulvio Reggiori,Vojo Deretic +14 more
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References
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Biomolecular condensates: organizers of cellular biochemistry
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Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles
Clotilde Théry,Muriel Boussac,Philippe Veron,Paola Ricciardi-Castagnoli,Graça Raposo,Jérôme Garin,Sebastian Amigorena +6 more
TL;DR: Using a systematic proteomic approach, the first extensive protein map of a particular exosome population is established and a novel category of exosomal proteins related to apoptosis is identified: thioredoxin peroxidase II, Alix, 14-3-3, and galectin-3.
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Galectins: a family of animal beta-galactoside-binding lectins.
Samuel H. Barondes,Vincent Castronovo,Douglas N.W. Cooper,Richard D. Cummings,Kurt Drickamer,Ten Felzi,Michael A. Gitt,Jun Hirabayashi,Colin Hughes,Ken-ichi Kasai,Hakon Leffler,Fu-Tong Liu,Reuben Lotan,Arthur M. Mercurio,Michel Monsigny,Shiv Pillai,Françoise Poirer,Avraham Raz,Peter W.J. Rigby,James M. Rini,John L. Wang +20 more
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Oligosaccharide specificity of galectins: a search by frontal affinity chromatography.
Jun Hirabayashi,Tomomi Hashidate,Yoichiro Arata,Nozomu Nishi,Takanori Nakamura,Mitsuomi Hirashima,Tadasu Urashima,Toshihiko Oka,Masamitsu Futai,Werner E.G. Müller,Fumio Yagi,Ken-ichi Kasai +11 more
TL;DR: In this paper, a frontal affinity chromatography (FAC) was used to quantitatively analyze the interactions at 20 °C between 13 galectins including 16 CRDs originating from mammals, chick, nematode, sponge, and mushroom, with 41 pyridylaminated (PA) oligosaccharides.