Journal ArticleDOI
The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.
Shigemi Sasawatari,Tadashi Okamura,Eiji Kasumi,Kaori Tanaka–Furuyama,Rieko Takanashi,Senji Shirasawa,Norihiro Kato,Noriko Toyama–Sorimachi +7 more
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TLDR
SLC15A4 promotes colitis through Toll-like receptor 9 and NOD1-dependent innate immune responses and functions as a transporter of the N OD1 ligand, suggesting Histidine homeostasis within intracellular compartments is important for eliciting effective innateimmune responses.About:
This article is published in Gastroenterology.The article was published on 2011-05-01. It has received 91 citations till now. The article focuses on the topics: Innate lymphoid cell & Toll-like receptor.read more
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Genetics and pathogenesis of inflammatory bowel disease
TL;DR: Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease, and the role of genetic predispositions and how they affect interactions with microbial and environmental factors is emphasized.
Journal ArticleDOI
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
TL;DR: Recent developments about the mechanisms by which NOD1 and NOD2 are activated by bacterial ligands, the regulation of their signaling pathways, and their role in host defense and inflammatory disease are discussed.
Journal ArticleDOI
Peptidoglycan recognition by the innate immune system
TL;DR: This Review discusses new insights into the role of peptidoglycan recognition in inflammation, metabolism, immune homeostasis and disease and focuses on the mechanisms that are used by mammalian cells.
Journal ArticleDOI
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.
TL;DR: In this review, updated information is provided on the structure-function of PepT1, PepT2, PhT1 and PhT2 and their expression and localization in key tissues, and as potential targets for drug delivery.
Journal ArticleDOI
Nod-like receptors: versatile cytosolic sentinels
TL;DR: Although initially described to respond to intracellular pathogens, NLRs have been shown to play important roles in distinct biological processes ranging from regulation of antigen presentation, sensing metabolic changes in the cell, modulation of inflammation, embryo development, cell death, and differentiation of the adaptive immune response.
References
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Journal ArticleDOI
T cell receptor antagonist peptides induce positive selection
Kristin A. Hogquist,Stephen C. Jameson,William R. Heath,Jane L Howard,Michael J. Bevan,Francis R. Carbone +5 more
TL;DR: Results show that the process of positive selection is exquisitely peptide specific and sensitive to extremely low ligand density and support the notion that low efficacy ligands mediate positive selection.
Journal ArticleDOI
IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L. Mellor,David H. Munn +1 more
TL;DR: This review summarizes key recent developments and proposes a unifying model for the role of IDO in tolerance induction, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases.
Journal ArticleDOI
Clinicopathologic study of dextran sulfate sodium experimental murine colitis
TL;DR: The finding of crypt loss without proceeding or accompanying inflammation suggests that the initial insult is at the level of the epithelial cell with inflammation being a secondary phenomena.
Journal ArticleDOI
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
Jochen Hampe,Andrew P. Cuthbert,Peter J. P. Croucher,Muddassar M. Mirza,Silvia Mascheretti,Sheila A. Fisher,Henning Frenzel,Katherine S. King,Anja Hasselmeyer,Andrew J. Macpherson,Stephen Bridger,Sander J. H. van Deventer,Alastair Forbes,Susanna Nikolaus,John E. Lennard-Jones,Ulrich R. Foelsch,Michael Krawczak,Cathryn M. Lewis,Stefan Schreiber,Christopher G. Mathew +19 more
TL;DR: The insertion mutation in the NOD2 gene confers a substantially increased susceptibility to Crohn's disease but not to ulcerative colitis.
Journal ArticleDOI
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
Daniel Rachmilewitz,Kyoko Katakura,Fanny Karmeli,Tomoko Hayashi,Constantin Reinus,Bernard Rudensky,Shizuo Akira,Kiyoshi Takeda,Jongdae Lee,Kenji Takabayashi,Eyal Raz +10 more
TL;DR: The protective effects of Probiotics are mediated by their own DNA rather than by their metabolites or ability to colonize the colon, and live microorganisms are not required to attenuate experimental colitis because nonviable probiotics are equally effective.
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