Journal ArticleDOI
The Wnt/β-catenin pathway in ovarian cancer: a review.
TLDR
The Wnt/β-catenin pathway is reviewed as it relates to epithelial ovarian cancer, specifically its role in chemoresistance and its potential role as a target for chemosensitization.About:
This article is published in Gynecologic Oncology.The article was published on 2013-12-01. It has received 370 citations till now. The article focuses on the topics: Wnt signaling pathway & Cancer stem cell.read more
Citations
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Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities.
Yazhuo Zhang,Yazhuo Zhang,Mengfang Xia,Mengfang Xia,Ke Jin,Shufei Wang,Hang Wei,Chunmei Fan,Yingfen Wu,Xiaoling Li,Xiaoling Li,Xiayu Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong +17 more
TL;DR: The molecular structure of c-Met and HGF and the mechanism through which their interaction activates the PI3K/AKT, Ras/MAPK, and Wnt signaling pathways are elaborate and the current therapeutic drugs targeted in primary tumors are introduced.
Journal ArticleDOI
Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance.
Anil Belur Nagaraj,Peronne Joseph,Olga Kovalenko,Sareena Singh,Amy Armstrong,Raymond W. Redline,Kimberly Resnick,Kristine M. Zanotti,Steven E. Waggoner,Analisa DiFeo +9 more
TL;DR: This data is the first report providing evidence that the Wnt/β-catenin signaling pathway maintains stem-like properties and drug resistance of primary HGSOC PDX derived platinum resistant models, and therapeutic targeting of this pathway with iCG-001/PRI-724, which has been shown to be well tolerated in Phase I trials, may be an effective treatment option.
Journal ArticleDOI
Isolation, identification, and characterization of cancer stem cells: A review.
Mohammad Reza Abbaszadegan,Vahid Bagheri,Mahya Shariat Razavi,Mahya Shariat Razavi,Amir Abbas Momtazi,Amirhossein Sahebkar,Mehran Gholamin +6 more
TL;DR: This review compiles information about different methods of detection and dissociation, side population, cellular markers, and establishment culture of CSCs, as well as characteristics of C SCs such as tumorigenicity, and signaling pathways associated with self‐renewal and the capability of the same histological tumor regeneration in various cancers.
Journal ArticleDOI
Exon 3 mutations of CTNNB1 drive tumorigenesis: a review.
TL;DR: The current understanding of CTNNB1 mutations, their roles in tumorigenesis and their possible therapeutic implications for cancer are reviewed.
Journal ArticleDOI
Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer
Zhi-Li Liu,Zhenyao Chen,Ruihua Fan,Bin Jiang,Xin Chen,Qinnan Chen,Fengqi Nie,Kaihua Lu,Ming Sun +8 more
TL;DR: Findings show that HOXA11-AS not only could promote GC cells migration and invasion in vitro, but also promotes GC cells metastasis in vivo, at least in part, by regulating β-catenin and KLF2.
References
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Journal ArticleDOI
Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study
Robert F. Ozols,Brian N. Bundy,Benjamin E. Greer,Jeffrey M. Fowler,Daniel L. Clarke-Pearson,Robert A. Burger,Robert S. Mannel,Koen DeGeest,Ellen M. Hartenbach,Rebecca N. Baergen +9 more
TL;DR: In patients with advanced ovarian cancer, a chemotherapy regimen consisting of carboplatin pluspaclitaxel results in less toxicity, is easier to administer, and is not inferior, when compared with cisplatin plus pac Litaxel.
Journal ArticleDOI
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih Min A Huang,Yuji Mishina,Shanming Liu,Atwood K. Cheung,Frank Stegmeier,Gregory A. Michaud,Olga Charlat,Elizabeth Wiellette,Yue Zhang,Stephanie Wiessner,Marc Hild,Xiaoying Shi,Christine D. Wilson,Craig Mickanin,Vic E. Myer,Aleem Fazal,Ronald Tomlinson,Fabrizio C. Serluca,Wenlin Shao,Hong Cheng,Michael Shultz,Christina Rau,Markus Schirle,Judith Schlegl,Sonja Ghidelli,Stephen Fawell,Chris Lu,Daniel Curtis,Marc W. Kirschner,Christoph Lengauer,Peter Finan,John A. Tallarico,Tewis Bouwmeester,Jeffery A. Porter,Andreas Bauer,Feng Cong +35 more
TL;DR: This study uses a chemical genetic screen to identify a small molecule, XAV939, which selectively inhibits β-catenin-mediated transcription and reveals new mechanistic insights into the regulation of axin protein homeostasis, which presents new avenues for targeted Wnt pathway therapies.
Journal ArticleDOI
The biology of ovarian cancer: new opportunities for translation
TL;DR: Increase in long-term survival in ovarian cancer patients might be achieved by translating recent insights at the molecular and cellular levels to personalize individual strategies for treatment and to optimize early detection.
Journal ArticleDOI
Female development in mammals is regulated by Wnt-4 signalling
TL;DR: In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development but the establishment of sexual dimorphism is under the control of both local and systemic signals.
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Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis.
TL;DR: In this paper, the authors provide a review of these reports and describe mechanisms to explain the morphologic and molecular heterogeneity and plasticity of malignant carcinoma cells, including incomplete epithelial to mesenchymal transition (EMT), reversion to an epithelial phenotype, and collective migration.
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