Journal ArticleDOI
Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications
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TLDR
In this article, the authors summarize synthesis strategies of water-soluble fluorescent metal nanoclusters and their optical properties, highlight recent advances in their application for ultrasensitive biological detection and fluorescent biological imaging, and finally discuss current challenges for their potential biomedical applications.About:
This article is published in Nano Today.The article was published on 2011-08-01. It has received 1306 citations till now. The article focuses on the topics: Nanoclusters.read more
Citations
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Pre-Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA-Templated Gold Nanoclusters
TL;DR: The results revealed that the pre-incubation of HAuCl4 with poly-adenine is not favorable for the formation of Au NCs, which is distinctly different from the formation process for silver nanoclusters.
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Templated in-situ synthesis of gold nanoclusters conjugated to drug target bacterial enoyl-ACP reductase, and their application to the detection of mercury ions using a test stripe
Han Ding,Hong-Wei Li,Pengchang Liu,J. Kalervo Hiltunen,J. Kalervo Hiltunen,Yuqing Wu,Zhijun Chen,Zhijun Chen,Jiacong Shen +8 more
TL;DR: In this paper, fluorescent gold nanoclusters (AuNCs) were synthesized using a drug target bacterial enoyl-ACP reductase (FabI) as a template, and the conjugated particles were loaded onto nylon membranes by taking advantage of the electrostatic interaction between the negatively charged AuNCs@FabI and the nylon film which is positively charged at pH 7.4.
Journal ArticleDOI
Detection of biotin-streptavidin interactions based on poly(thymine)-templated copper nanoparticles coupled with Exo III-aided DNA recycling amplification
Yue He,Bining Jiao +1 more
TL;DR: A highly sensitive and label-free fluorescent assay for small molecule–protein interactions on the basis of exonuclease III (Exo III)-assisted signal amplification and poly(thymine)-templated fluorescent copper nanoparticles (CuNPs) as signal probes is constructed.
Journal ArticleDOI
Enhancement of Internal Motions of Lysozyme through Interaction with Gold Nanoclusters and its Optical Imaging
Sathish Kumar Mudedla,E. R. Azhagiya Singam,J. Vijay Sundar,Morten N. Pedersen,N. Arul Murugan,Jacob Kongsted,Hans Ågren,Venkatesan Subramanian +7 more
TL;DR: A study of the interaction between gold nanoclusters and lysozyme investigated using classical molecular dynamics and center-of-mass pulling simulations reveals that the gold nanocusters induce significant structural changes in lyso enzyme.
Journal ArticleDOI
Ultrasound-mediated modulation of the emission of gold nanodots
Yu-Ting Tseng,Rochelle Cherng,Zhiqin Yuan,Chien-Wei Wu,Huan-Tsung Chang,Chih-Ching Huang,Chih-Ching Huang +6 more
TL;DR: The dramatically different optical properties of these alkanethiol-protected Au NDs after ultrasonication were presumably due to variation in their ligand densities; these effects were highly regulated by varying the ultrasonic treatment time and power.
References
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Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Localized Surface Plasmon Resonance Spectroscopy and Sensing
TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
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Luminescent Carbon Nanodots: Emergent Nanolights
Sheila N. Baker,Gary A. Baker +1 more
TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
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The fluorescent toolbox for assessing protein location and function
TL;DR: The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy.
Journal ArticleDOI
Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
Daniel R. Larson,Warren R. Zipfel,Rebecca M. Williams,S. W. Clark,Marcel P. Bruchez,Frank W. Wise,Watt W. Webb +6 more
TL;DR: This work characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals and found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.