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Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications

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TLDR
In this article, the authors summarize synthesis strategies of water-soluble fluorescent metal nanoclusters and their optical properties, highlight recent advances in their application for ultrasensitive biological detection and fluorescent biological imaging, and finally discuss current challenges for their potential biomedical applications.
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This article is published in Nano Today.The article was published on 2011-08-01. It has received 1306 citations till now. The article focuses on the topics: Nanoclusters.

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Citations
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Papain-directed synthesis of luminescent gold nanoclusters and the sensitive detection of Cu2+.

TL;DR: Highly fluorescent papain stabilized gold nanoclusters (NCs) have been synthesized through a simple wet chemical route and the sensing strategy is also highly selective against the various potential interference ions.
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Fluorescence Dynamics in BSA-Protected Au25 Nanoclusters

TL;DR: In this article, the authors investigate the fluorescence dynamics in BSA-protected Au25 nanoclusters by time-resolved photoluminescence and transient absorption techniques covering picosecond to microsecond time scales.
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11-Mercaptoundecanoic acid directed one-pot synthesis of water-soluble fluorescent gold nanoclusters and their use as probes for sensitive and selective detection of Cr3+ and Cr6+

TL;DR: In this paper, a one-pot approach to prepare fluorescent gold nanoclusters (AuNCs) from HAuCl4 by simply using 11-mercaptoundecanoic acid (11-MUA) as a reducing and capping agent, in an aqueous solution of NaOH at room temperature.
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Facile one-pot synthesis of l-proline-stabilized fluorescent gold nanoclusters and its application as sensing probes for serum iron

TL;DR: Based on the aggregation-induced fluorescence quenching mechanism, the Au NCs provided favorable biocompatibility, high sensitivity and good selectivity for the measurement of ferric ion (Fe(3+)).
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Nanoscale chirality in metal and semiconductor nanoparticles

TL;DR: This work discusses optical activity in metal nanoclusters and semiconductor quantum dots, broadly focusing on recent advances in nanoscale chirality in plasmonic nanoparticles and their assemblies.
References
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Journal ArticleDOI

Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Localized Surface Plasmon Resonance Spectroscopy and Sensing

TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
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Luminescent Carbon Nanodots: Emergent Nanolights

TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
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The fluorescent toolbox for assessing protein location and function

TL;DR: The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy.
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Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo

TL;DR: This work characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals and found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.
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