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Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications

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TLDR
In this article, the authors summarize synthesis strategies of water-soluble fluorescent metal nanoclusters and their optical properties, highlight recent advances in their application for ultrasensitive biological detection and fluorescent biological imaging, and finally discuss current challenges for their potential biomedical applications.
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This article is published in Nano Today.The article was published on 2011-08-01. It has received 1306 citations till now. The article focuses on the topics: Nanoclusters.

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Journal ArticleDOI

Ligand effect on the size, valence state and red/near infrared photoluminescence of bidentate thiol gold nanoclusters.

TL;DR: The effect of temperature and pH on the optical properties of gold clusters is strongly dependent on the ligand shell and demonstrates the importance of defining gold nanoclusters as supramolecular assemblies with a complex environment.
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Synthesis of highly fluorescent lysine-stabilized Au nanoclusters for sensitive and selective detection of Cu2+ ion

TL;DR: In this article, highly fluorescent lysine-stabilized Au nanoclusters (AuNCs@Lys) were successfully synthesized by a simple and environmental friendly approach.
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Isolating reactive metal-based species in Metal–Organic Frameworks – viable strategies and opportunities

TL;DR: The growing body of work whereby reactive species can be isolated and structurally characterised within a MOF matrix will be reviewed, including discussion of salient examples and the provision of useful guidelines for the design of new systems.
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On–Off–On Gold Nanocluster-Based Fluorescent Probe for Rapid Escherichia coli Differentiation, Detection and Bactericide Screening

TL;DR: This work presents a novel strategy for rapid Escherichia coli differentiation, detection and bactericide screening, by employing an on–off–on gold nanocluster (AuNC)-based fluorescent probe, and demonstrates that by hijacking their copper-binding and redox pathways to capture and reduce Cu2+, E. coli bacteria can selectively and efficiently recover the fluorescence of AuNC from Cu2-caused quenching.
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Chemically modified cellulose strips with pyridoxal conjugated red fluorescent gold nanoclusters for nanomolar detection of mercuric ions

TL;DR: One-pot approach was adopted for the synthesis of highly luminescent near-infrared (NIR)-emitting gold nanoclusters (AuNCs) using bovine serum albumin (BSA) as a protecting agent and nano-assembly was successfully applied for the real sample analysis of Hg2+ in fish, tap water and river water.
References
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Journal ArticleDOI

Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Localized Surface Plasmon Resonance Spectroscopy and Sensing

TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
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Luminescent Carbon Nanodots: Emergent Nanolights

TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
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The fluorescent toolbox for assessing protein location and function

TL;DR: The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy.
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Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo

TL;DR: This work characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals and found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.
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