Journal ArticleDOI
Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications
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In this article, the authors summarize synthesis strategies of water-soluble fluorescent metal nanoclusters and their optical properties, highlight recent advances in their application for ultrasensitive biological detection and fluorescent biological imaging, and finally discuss current challenges for their potential biomedical applications.About:
This article is published in Nano Today.The article was published on 2011-08-01. It has received 1306 citations till now. The article focuses on the topics: Nanoclusters.read more
Citations
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NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors
Haixia Li,Hao Dong,Mingming Yu,Chunxia Liu,Zhanxian Li,Liuhe Wei,Ling-Dong Sun,Hongyan Zhang +7 more
TL;DR: The as-developed nanosensor not only exhibits good antidisturbance ability, but it also can reversibly sense pH and linearly sense pH in a range of 6.0-9.0 from absorption and upconversion emission spectra, respectively.
Journal ArticleDOI
Sensitive Detection of Single-Cell Secreted H2O2 by Integrating a Microfluidic Droplet Sensor and Au Nanoclusters.
Rui Shen,Peipei Liu,Yiqiu Zhang,Zhao Yu,Xuyue Chen,Lu Zhou,Baoqing Nie,Anna J. Żaczek,Jian Chen,Jian Liu +9 more
TL;DR: An ultrahigh sensitivity (200-400 attomole H2O2 directly measured from a single cell) with good specificity is demonstrated and offers a useful research tool to study the cell-to-cell differences of H 2O2 secretion at the single-cell level.
Journal ArticleDOI
Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing
Jian Sun,Fan Yang,Xiurong Yang +2 more
TL;DR: A reliable AuNC@GSH/MUA-based real-time assay of acid phosphatase (ACP) is established for the first time, inspired by the selective coordination of Fe(3+) with surface ligands of AuNCs, the higher binding affinity between the pyrophosphate ion (PPi) andFe(3+), and the hydrolysis of PPi into orthophosphate by ACP.
Journal ArticleDOI
Correlation of photobleaching, oxidation and metal induced fluorescence quenching of DNA-templated silver nanoclusters
TL;DR: Electronic absorption and mass spectrometry studies offered further insights into the oxidation reaction, and the results correlate many important experimental observations and will fuel the further growth of this field.
Journal ArticleDOI
The synthesis of high bright silver nanoclusters with aggregation-induced emission for detection of tetracycline
TL;DR: In this article, the silver nanoclusters (Ag NCs) with aggregation-induced emission property were synthesized successfully by reflux method using silver nitrate (AgNO3) as raw material and Nacetyl-L-cysteine (NAC) as the reductant and capped ligand.
References
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Localized Surface Plasmon Resonance Spectroscopy and Sensing
TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
Journal ArticleDOI
Luminescent Carbon Nanodots: Emergent Nanolights
Sheila N. Baker,Gary A. Baker +1 more
TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
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The fluorescent toolbox for assessing protein location and function
TL;DR: The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy.
Journal ArticleDOI
Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
Daniel R. Larson,Warren R. Zipfel,Rebecca M. Williams,S. W. Clark,Marcel P. Bruchez,Frank W. Wise,Watt W. Webb +6 more
TL;DR: This work characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals and found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.