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Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications

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TLDR
In this article, the authors summarize synthesis strategies of water-soluble fluorescent metal nanoclusters and their optical properties, highlight recent advances in their application for ultrasensitive biological detection and fluorescent biological imaging, and finally discuss current challenges for their potential biomedical applications.
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This article is published in Nano Today.The article was published on 2011-08-01. It has received 1306 citations till now. The article focuses on the topics: Nanoclusters.

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Double strand DNA-templated copper nanoparticle as a novel fluorescence indicator for label-free detection of polynucleotide kinase activity.

TL;DR: A label-free fluorescent method for PNK activity assay using double strand DNA -templated copper nanoparticles (CuNPs) as a fluorescent indicator, which is sensitive, selective and exhibits a good assay performance in complex biological samples.
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Cu2 + modulated BSA–Au nanoclusters: A versatile fluorescence turn-on sensor for dopamine

TL;DR: In this article, a modified BSA stabilized gold nanoclusters (BSA-Au NCs) were fabricated for the fluorescence turn-on detection of dopamine, an important catecholamine neurotransmitter.
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Determination of Hg2+ and Cu2+ ions by dual-emissive Ag/Au nanocluster/carbon dots nanohybrids: Switching the selectivity by pH adjustment

TL;DR: An innovative dual-emissive ratiometric nanohybrid probe comprised of red-emitting a (Ag/Au)@insulin nanoclusters (NCs) and blue-emitted carbon dots (CDs) was designed for sensitive and selective ratiometry determination of Hg2+ and Cu2+ ions.
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Understanding the Surface Chemistry of Thiolate-Protected Metallic Nanoparticles

TL;DR: In this article, the complexity of the thiol-metal NP interface chemistry and how this changes with the nature of the metallic core is discussed. And the most common strategy to protect these NPs is by using thiolate self-assembled monolayers, a strategy that has proved to be useful to control the physical and chemical properties of extended solid surfaces.
References
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Journal ArticleDOI

Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Localized Surface Plasmon Resonance Spectroscopy and Sensing

TL;DR: This review describes recent fundamental spectroscopic studies that reveal key relationships governing the LSPR spectral location and its sensitivity to the local environment, including nanoparticle shape and size and introduces a new form of L SPR spectroscopy, involving the coupling between nanoparticle plasmon resonances and adsorbate molecular resonances.
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Luminescent Carbon Nanodots: Emergent Nanolights

TL;DR: This Review summarize recent advances in the synthesis and characterization of C-dots and speculate on their future and discuss potential developments for their use in energy conversion/storage, bioimaging, drug delivery, sensors, diagnostics, and composites.
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The fluorescent toolbox for assessing protein location and function

TL;DR: The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy.
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Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo

TL;DR: This work characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals and found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.
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