VEGF-A Regulates Cellular Localization of SR-BI as Well as Transendothelial Transport of HDL but Not LDL.
Srividya Velagapudi,Mustafa Yalcinkaya,Antonio Piemontese,Roger Meier,Simon F. Norrelykke,Damir Perisa,Andrzej J. Rzepiela,Michael Stebler,Szymon Stoma,Paolo Zanoni,Lucia Rohrer,Arnold von Eckardstein +11 more
TLDR
The identification of VEGF as a regulatory factor of transendothelial transport of HDL but not LDL supports the concept that the endothelium is a specific and, hence, druggable barrier for the entry of lipoproteins into the vascular wall.Abstract:
Objective—Low- and high-density lipoproteins (LDL and HDL) must pass the endothelial layer to exert pro- and antiatherogenic activities, respectively, within the vascular wall. However, the rate-li...read more
Citations
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Journal ArticleDOI
Endothelial Transcytosis of Lipoproteins in Atherosclerosis.
TL;DR: A better understanding of the mechanisms that mediate lipoprotein transcytosis across ECs will help to develop therapies targeting the early events of atherosclerosis and thus exert potential benefits for treating atherosclerotic vascular disease.
Journal ArticleDOI
Endocytosis of lipoproteins.
TL;DR: During their metabolism, all lipoproteins undergo endocytosis, either to be degraded intracellularly, for example in hepatocytes or macrophages, or to be re-secreted, for instance in the course of transcytosis by endothelial cells.
Journal ArticleDOI
Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis
Mohammad Ishraq Zafar,Kerry E Mills,Xiaofeng Ye,Brette Blakely,Jie Min,Wen Kong,Nan Zhang,Luoning Gou,Anita Regmi,Sheng Qing Hu,Juan Zheng,Lu Lu Chen +11 more
TL;DR: The increased concentrations of vascular endothelial growth factors are variably associated with metabolic syndrome or its components and each VEGF protein has a unique set of associations with the disease state.
Journal ArticleDOI
High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential.
A Jomard,Elena Osto,Elena Osto +2 more
TL;DR: The novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality is explored.
Journal ArticleDOI
High-Density Lipoprotein Function in Cardiovascular Disease and Diabetes Mellitus.
TL;DR: It remains uncertain whether increased HDL-C directly impacts atherosclerosis and the consequences may be indirect or more complicated than previously recognized.
References
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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Birgit Millauer,Susanne Wizigmann-Voos,Harald Schnürch,Ricardo Martinez,Niels Møller,Werner Risau,Axel Ullrich +6 more
TL;DR: Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.
Journal ArticleDOI
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
TL;DR: Neither the receptor-associated activity of phosphatidylinositol 3'-kinase nor tyrosine phosphorylation of phospholipase C-gamma were affected by stimulation of Flt1 or KDR expressing cells, and phosphorylated of GTPase activating protein was only slightly increased.
Journal ArticleDOI
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
Vladimir Joukov,Katri Pajusola,Arja Kaipainen,Dmitri Chilov,Isto Lahtinen,Eola Kukk,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
TL;DR: VEGF‐C is a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
Journal ArticleDOI
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
Bruce I. Terman,Maureen Dougher-Vermazen,Miguel Eduardo Carrion,Dragan Dimitrov,Douglas C. Armellino,Denis Gospodarowicz,Peter Bohlen +6 more
TL;DR: The KDR receptor tyrosine kinase shares structural similarities with a recently reported receptor for VEGF, flt, in a manner reminiscent of the similarities between the alpha and beta forms of the PDGF receptors.
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