Journal ArticleDOI
Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation
TLDR
The data suggest that vitexin ameliorates ox‐LDL‐mediated endothelial injury by inducing autophagy via AMPK signaling, and promotes cell viability and suppresses apoptosis in ox‐ LDL‐treated HUVECs.About:
This article is published in Molecular Immunology.The article was published on 2017-05-01. It has received 43 citations till now. The article focuses on the topics: Vitexin & AMPK.read more
Citations
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Journal ArticleDOI
Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical
Ye Peng,Ren-You Gan,Hua-Bin Li,Mingxuan Yang,David Julian McClements,Ruichang Gao,Quancai Sun +6 more
TL;DR: Improved knowledge of the absorption, metabolism, bioactivity, and molecular targets of vitexin is crucial for the better utilization of this emerging nutraceutical as a chemopreventive and chemotherapeutic agent.
Journal ArticleDOI
Galectin-3 Is a Potential Mediator for Atherosclerosis.
TL;DR: This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal- 3 agonists and antagonists in the current studies.
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Review of the effects of vitexin in oxidative stress-related diseases.
Fatemeh Babaei,Armita Moafizad,Zahra Darvishvand,Mohammadreza Mirzababaei,Hossein Hosseinzadeh,Marjan Nassiri-Asl +5 more
TL;DR: All the protective effects of vitexin as an antioxidant against reactive oxygen species, lipid peroxidation, and other oxidative damages in a variety of oxidative stress‐related diseases are summarized.
Journal ArticleDOI
Flavonoids: Broad Spectrum Agents on Chronic Inflammation.
TL;DR: These pharmacological actions with newly emerging activities render flavonoids to be potential therapeutics for chronic inflammatory disorders including arthritic inflammation, meta- inflammation, and inflammaging.
References
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Autophagy in the Pathogenesis of Disease
TL;DR: This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
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Autophagy fights disease through cellular self-digestion
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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Autophagosome formation: core machinery and adaptations
Zhiping Xie,Daniel J. Klionsky +1 more
TL;DR: A core molecular machinery has a critical role in forming sequestering vesicles, the autophagosome, which is the hallmark morphological feature of this dynamic process.
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Role of autophagy in cancer
TL;DR: Evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress.