Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
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Journal ArticleDOI
Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity.
Gry Irene Skodje,Gry Irene Skodje,Vikas Kumar Sarna,Vikas Kumar Sarna,Ingunn Hillestad Minelle,Kjersti Langballe Rolfsen,Jane G. Muir,Peter R. Gibson,Marit B. Veierød,Christine Henriksen,Knut E.A. Lundin +10 more
TL;DR: In a randomized, double-blind, placebo-controlled crossover study of individuals with self-reported non-celiac gluten sensitivity, fructans to induce symptoms, measured by the Gastrointestinal Symptom Rating Scale Irritable Bowel Syndrome (GSRS-IBS).
Journal ArticleDOI
The many faces of celiac disease: Clinical presentation of celiac disease in the adult population
TL;DR: There is a need for screening studies of patients with conditions associated with celiac disease to determine whether the large numbers of people with undiagnosed Celiac disease currently are seeking health care.
Journal ArticleDOI
Update on serologic testing in celiac disease.
TL;DR: The need to develop tests for CD activity in order to assess the efficacy of upcoming nondietary therapies is discussed and the evidence for preferential use of specific tests in different settings is reviewed.
Journal ArticleDOI
A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial.
Heidi M Staudacher,Miranda Lomer,Miranda Lomer,Freda M. Farquharson,Petra Louis,Francesca Fava,Elena Franciosi,Matthias Scholz,Kieran Tuohy,James O. Lindsay,James O. Lindsay,Peter M. Irving,Peter M. Irving,Kevin Whelan +13 more
TL;DR: In a placebo-controlled study of patients with IBS, a low FODMAP diet associates with adequate symptom relief and significantly reduced symptom scores compared with placebo.
Journal ArticleDOI
Management of heartburn not responding to proton pump inhibitors
Ronnie Fass,Daniel Sifrim +1 more
TL;DR: In this article, the failure of proton pump inhibitors (PPIs) treatment may result in the addition of a transient lower oesophageal sphincter reducer or pain modulator.