Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
References
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Journal ArticleDOI
Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study.
Massimo Montalto,Gabriella Nucera,Luca Santoro,Valentina Curigliano,Monica Vastola,Marcello Covino,Lucio Cuoco,Raffaele Manna,Antonio Gasbarrini,Giovanni Gasbarrini +9 more
TL;DR: The study shows that in lactose malabsorbers with intolerance, the lactase obtained from K. lactis can represent a valid therapeutic strategy, with objective and subjective efficacy and without side effects.
Journal ArticleDOI
Irritable bowel syndrome and diet.
TL;DR: This paper will focus on available dietary interventions for IBS and will review the evidence for nutrition-based therapies and new therapeutic agents, namely nutraceutics, which are also an interesting option in the management of IBS patients.
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Mass Administration of Ivermectin for the Elimination of Onchocerciasis Significantly Reduced and Maintained Low the Prevalence of Strongyloides stercoralis in Esmeraldas, Ecuador.
Mariella Anselmi,Dora Buonfrate,Ángel Gustavo Guevara Espinoza,Rosanna Prandi,Monica Marquez,Maria Gobbo,Antonio Montresor,Marco Albonico,Marcia Racines Orbe,Juan Moreira,Zeno Bisoffi +10 more
TL;DR: periodic mass distribution of ivermectin had a significant impact on the prevalence of strongyloidiasis, less on trichuriasis and apparently no effect on ascariasis and hookworm infections.
Journal ArticleDOI
Role of Fiber in Symptomatic Uncomplicated Diverticular Disease: A Systematic Review.
TL;DR: The benefit of dietary or supplemental fiber in SUDD patients still needs to be established, as single studies suggest that fibers, both dietary and supplemental, could be beneficial in SudD, even if the quality is very low, with just one study yielding an optimal score.
Journal ArticleDOI
The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review.
Paul Moayyedi,Eamonn Martin Quigley,Brian E. Lacy,Anthony Lembo,Yuri A. Saito,Lawrence R. Schiller,Edy E. Soffer,Brennan Spiegel,Alexander C. Ford +8 more
TL;DR: More evidence is needed before generally recommending elimination diets for IBS patients, as the evidence for the efficacy of dietary therapies has not been evaluated systematically.