Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
References
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Journal ArticleDOI
Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area.
Juan C. Gomez,Gisella S. Selvaggio,Martı́n Viola,Bibiana Pizarro,G la Motta,S de Barrio,Roberto Castelletto,Raul Echeverria,Emilia Sugai,Horacio Vázquez,Eduardo Mauriño,Julio C. Bai +11 more
TL;DR: The screening protocol showed a very high prevalence of celiac disease for an urban area of Argentina that is ethnically similar to 90% of the general population of the country, and the heterogeneous clinical picture of new patients showed predominance of asymptomatic cases.
Journal ArticleDOI
Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis.
TL;DR: Available evidence does not support emergency sclerotherapy as the first-line treatment of variceal bleeding in cirrhosis when compared with vasoactive drugs, which control bleeding in 83% of patients, and endoscopic therapy might be added only in pharmacologic treatment failures.
Journal ArticleDOI
Celiac disease diagnosis: simple rules are better than complicated algorithms.
TL;DR: Clinically useful the shifting to a quantitative approach that can be defined as the "4 out of 5" rule: the diagnosis of celiac disease is confirmed if at least 4 of the following 5 criteria are satisfied: typical symptoms of Celiac disease; positivity of serum celiac Disease immunoglobulin, A class autoantibodies at high titer.
Journal ArticleDOI
World Gastroenterology Organisation global guideline: Constipation--a global perspective.
Greger Lindberg,Saeed Hamid,Peter Malfertheiner,Ole Østergaard Thomsen,Luis M. Bustos Fernandez,James Garisch,Alan B. R. Thomson,Khean-Lee Goh,Rakesh K. Tandon,S. Fedail,Benjamin C.Y. Wong,Aamir Ghafoor Khan,Justus Krabshuis,Anton LeMair +13 more
TL;DR: This guideline focuses on adult patients and does not specifically discuss children or special groups of patients (such as those with spinal cord injury), but there are 2 pathophysiologies which differ in principle but overlap: disorders of transit and evacuation disorders.
Journal ArticleDOI
Systematic review: The effects of fibre in the management of chronic idiopathic constipation
TL;DR: Aliment Pharmacol Ther 2011; 33; 33: 895–901.