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World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
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Journal Article
Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Commentary
Muhammed Hadithi,B. Mary E. von Blomberg,J. Bart A. Crusius,Elisabeth Bloemena,Pieter J. Kostense,Jos W. R. Meijer,Chris J. J. Mulder,Coen D.A. Stehouwer,Amado Salvador Peña,Shadi Rashtak,Joseph A. Murray +10 more
TL;DR: Serologic tests could not substitute for small-bowel biopsy in the diagnostic work-up of celiac disease, and the combination of genetic typing and serologic testing is about as accurate as either strategy alone.
Journal ArticleDOI
Brazilian Consensus on Gastroesophageal Reflux Disease: Proposals for assessment, classification, and management
Joaquim Prado P Moraes-Filho,Ivan Cecconello,Joaquim Gama-Rodrigues,Luiz de Paula Castro,Maria Aparecida Henry,Ulisses G. Meneghelli,Eamonn Martin Quigley +6 more
TL;DR: A new classification is proposed that combines three criteria-clinical, endoscopic, and pH-metric-providing a comprehensive and more complete characterization of the disease.
Journal ArticleDOI
Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans.
H. Rogier van Doorn,Rob Koelewijn,Henk Hofwegen,Henk Gilis,Jose C. F. M. Wetsteyn,Pieter J. Wismans,Claudine Sarfati,Tony Vervoort,Tom van Gool +8 more
TL;DR: The data suggest that all four ELISAs developed and evaluated are sensitive and specific tests for the diagnosis of both intestinal and cutaneous strongyloidiasis.
Journal ArticleDOI
Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs.
TL;DR: A two-day international multidisciplinary workshop was held in Marrakech, Morocco, in September 2002 to address these issues as discussed by the authors, which critically reviewed the data regarding the reliability, processes, and priorities for symptom evaluation in gastro-oesophageal reflux disease patients.
Journal ArticleDOI
Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care--the ProGERD study.
Peter Malfertheiner,Marc Nocon,Michael Vieth,Manfred Stolte,D. Jaspersen,Hans Rudolf Koelz,J. Labenz,Andreas Leodolter,Tore Lind,Kai Richter,S.N. Willich +10 more
TL;DR: Aliment Pharmacol Ther 2012; 35: 154–164