Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
References
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Journal ArticleDOI
New algorithm for the treatment of gastro-oesophageal reflux disease.
Gnj Tytgat,Kenneth E.L. McColl,Jan Tack,Gerald Holtmann,Richard H. Hunt,Peter Malfertheiner,A. P. S. Hungin,Hannah Batchelor +7 more
TL;DR: In this paper, a panel of international experts met to discuss the principles and practice of treating Gastro-oesophageal reflux disease (GERD) and developed an algorithm for the management of GERD, which can be followed by pharmacists, for over-thecounter medications, primary care physicians, or secondary care gastroenterologists.
Journal ArticleDOI
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Ruth Harvie,Alexandra Chisholm,Jordan E. Bisanz,Jeremy P. Burton,Peter Herbison,Kim Schultz,Michael Schultz +6 more
TL;DR: This study demonstrated that a reduction in FodMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs.
Journal ArticleDOI
Celiac disease serology in patients with different pretest probabilities: is biopsy avoidable?
Emilia Sugai,María de Lourdes Moreno,Hui J Hwang,Ana Cabanne,Adriana Crivelli,Fabio Nachman,Horacio Vázquez,Sonia I. Niveloni,Julio Argonz,Roberto M. Mazure,Graciela La Motta,Maria E. Caniggia,Edgardo Smecuol,N. Chopita,Juan C. Gomez,Eduardo Mauriño,Julio C. Bai +16 more
TL;DR: The DGP/tTG Screen assay could be considered as the best initial test for CD and Combinations of two tests might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects.
Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines Irritable Bowel Syndrome: A Global Perspective Update September 2015.
Eamonn Martin Quigley,Michael Fried,Kok-Ann Gwee,I. Khalif,A. P. S. Hungin,Greger Lindberg,Zaigham Abbas,Luis M. Bustos Fernandez,Shobna Bhatia,Max Schmulson,Carolina Olano,Anton LeMair +11 more
Journal ArticleDOI
Bones in coeliac disease: diagnosis and treatment
TL;DR: In coeliacs, the presence of an increased fracture risk was recently questioned and its importance on clinical grounds was reconsidered, in view of the fact that gluten-free diet generally improves bone mass and, consequently, reduces fracture risk.