Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
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Journal ArticleDOI
Use of the low-FODMAP diet in inflammatory bowel disease
Peter R. Gibson,Peter R. Gibson +1 more
TL;DR: Low‐FODMAP diet is a viable option for IBS‐like symptoms but should be carefully supervised to mitigate risk and the risk of compromising nutritional status with a restrictive diet must be seriously considered.
Journal ArticleDOI
Enzyme-Substitution Therapy with the Yeast Saccharomyces cerevisiae in Congenital Sucrase-Isomaltase Deficiency
TL;DR: Patients with congenital sucrase-isomaltase deficiency who intentionally or unintentionally consume sucrose can ameliorate the malabsorption by subsequently ingesting a small amount of viable yeast cells, preferably on a full stomach.
Journal ArticleDOI
Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study.
Guy D. Eslick,Nicholas J. Talley +1 more
TL;DR: Cardiac risk factors (high cholesterol and smoking) were independently associated with GERD, andQoL was significantly impaired regardless of the severity of GERD for the QoL domains physical function, body pain, vitality, and social function.
Journal ArticleDOI
How to institute the low-FODMAP diet.
TL;DR: A diet low in poorly absorbed, fermentable, short chain carbohydrates (FODMAPs) is an effective strategy to manage symptoms of irritable bowel syndrome (IBS), but research suggests that a strict long‐term, low‐FodMAP diet may negatively impact intestinal microbiome.
Journal ArticleDOI
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control
Marco Albonico,Sören L. Becker,Sören L. Becker,Sören L. Becker,Peter Odermatt,Peter Odermatt,Andrea Angheben,Mariella Anselmi,Arancha Amor,Beatrice Barda,Beatrice Barda,Dora Buonfrate,Philip J. Cooper,Laurent Getaz,Jennifer Keiser,Jennifer Keiser,Virak Khieu,Virak Khieu,Virak Khieu,Antonio Montresor,Jose Muñoz,Ana Requena-Méndez,Lorenzo Savioli,Richard Speare,Peter Steinmann,Peter Steinmann,Lisette van Lieshout,Jürg Utzinger,Jürg Utzinger,Zeno Bisoffi +29 more
TL;DR: Lack of point-of-care (POC) diagnostics and poor availability of, and access to, ivermectin are the two most significant bottlenecks that hinder effective management of the disease both in clinical and in public health settings.