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World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
References
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Journal ArticleDOI
HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis
Ludvig M. Sollid,Erik Thorsby +1 more
TL;DR: The evidence behind this concept that a particular HLA-DQ heterodimer, encoded by the DQA1*0501 and DQB1*0201 genes in cis or trans configuration, confers the primary disease susceptibility is reviewed.
Journal ArticleDOI
Appropriate acid suppression for the management of gastro-oesophageal reflux disease.
TL;DR: Preliminary meta-analysis shows that the healing rate of erosive oesophagitis at 8 weeks by antisecretory agents is directly related to the duration of suppression of gastric acid secretion achieved over a 24-hour period.
Journal ArticleDOI
Strongyloides stercoralis: Global Distribution and Risk Factors.
Fabian Schär,Ulf Trostdorf,Ulf Trostdorf,Federica Giardina,Federica Giardina,Virak Khieu,Virak Khieu,Virak Khieu,Sinuon Muth,Hanspeter Marti,Hanspeter Marti,Penelope Vounatsou,Penelope Vounatsou,Peter Odermatt,Peter Odermatt +14 more
TL;DR: The findings show high infection prevalence rates in the general population in selected countries and geographical regions and an association between HIV-infection/alcoholism and S. stercoralis infection.
Journal ArticleDOI
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
Derrick K Ong,Shaylyn B Mitchell,Shaylyn B Mitchell,Jacqueline Susanne Barrett,Susan Joy Shepherd,Peter M. Irving,Jessica R Biesiekierski,Stuart C. Smith,Peter R. Gibson,Jane G. Muir +9 more
TL;DR: Reduction of short‐chain poorly absorbed carbohydrates (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome, and symptoms produced in response to diets that differed only in FODMAP content are compared.
Journal ArticleDOI
Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials
TL;DR: Limited, moderate quality evidence is provided that searching for and eradicating H pylori reduces the incidence of gastric cancer in healthy asymptomatic infected Asian individuals, but these data cannot necessarily be extrapolated to other populations.