Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease.
Richard H. Hunt,David Armstrong,Peter H. Katelaris,Mary Afihene,Abate Bane,Shobna Bhatia,Minhu Chen,Myung Gyu Choi,Angelita Cristine de Melo,Kwong Ming Fock,Alex Ford,Michio Hongo,Aamir G. Khan,Leonid B. Lazebnik,Greger Lindberg,Maribel Lizarzábal,Thein Myint,Joaquim Prado P Moraes-Filho,Graciela Salis,Jaw-Town Lin,Raj Vaidya,Abdelmounen Abdo,Anton LeMair +22 more
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A century ago, Elie Metchnikoff postulated that lactic acid bacteria offered health benefits capable of promoting longevity and suggested that “intestinal autoint” bacteria should be studied.Abstract:
PROBIOTICS—THE CONCEPTHistory and DefinitionsA century ago, Elie Metchnikoff (a Russian scientist, Nobel laureate, and professor at the Pasteur Institute in Paris) postulated that lactic acid bacteria (LAB) offered health benefits capable of promoting longevity. He suggested that “intestinal autointread more
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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial
Ann-Lii Cheng,Zhongzhen Guan,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Tsai Sheng Yang,Won Young Tak,Hongming Pan,Shiying Yu,Jianming Xu,Fang Fang,Jessie Zou,Giuseppe Lentini,D. Voliotis,Yoon-Koo Kang +15 more
TL;DR: Experimental analyses suggest that sorafenib is effective for patients from the AP region with advanced HCC, irrespective of baseline status, and the efficacy and safety profiles in the subpopulations described were comparable with those in the overall study population.
Journal ArticleDOI
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
TL;DR: The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
Journal ArticleDOI
Bifidobacteria and Their Health-Promoting Effects.
Claudio Hidalgo-Cantabrana,Susana Delgado,Lorena Ruiz,Patricia Ruas-Madiedo,Borja Sánchez,Abelardo Margolles +5 more
TL;DR: The role of bifidobacteria as members of the human intestinal microbiota and their use as probiotic microorganisms in the prevention and treatment of disease are focused on.
Journal ArticleDOI
Optimum duration of regimens for Helicobacter pylori eradication
Yuhong Yuan,Alexander C. Ford,Khurram J. Khan,Javier P. Gisbert,David Forman,Grigorios I. Leontiadis,Frances Tse,Xavier Calvet,Carlo A Fallone,Lori A. Fischbach,Giuseppina Oderda,Franco Bazzoli,Paul Moayyedi +12 more
TL;DR: The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy.
Journal ArticleDOI
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation
Dong-Sheng Huang,Zhaohui Wang,Xujun He,Bill H. Diplas,Rui Yang,Patrick J. Killela,Qun Meng,Zai-Yuan Ye,Wei Wang,Xiao-Ting Jiang,Li Xu,Xiang-Lei He,Zhong-Sheng Zhao,Wen-Juan Xu,Hui-Ju Wang,Ying-Yu Ma,Ying-Jie Xia,Li Li,Ru-Xuan Zhang,Tao Jin,Zhong-kuo Zhao,Ji Xu,Sheng Yu,Fang Wu,Junbo Liang,Wang Sizhen,Yuchen Jiao,Hai Yan,Hou-Quan Tao +28 more
TL;DR: TERT promoter mutations are frequent in multiple tumour types and have similar distributions in Chinese cancer patients, making them potential therapeutic targets.
References
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Journal ArticleDOI
A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial.
TL;DR: It is hypothesized that sleeping left-side down with the head/torso elevated reduces recumbent gastroesophageal reflux (GER) and a sleep-positioning device consisting of an inclined base and body pillow that maintains lateral position while elevating the head /torso maintains recumbents position effectively.
Journal ArticleDOI
Predictors of gastroesophageal reflux symptoms in pregnant women screened for sleep disordered breathing: a secondary analysis.
TL;DR: This study suggests that GERD symptoms correlate with pre-pregnancy BMI and BMI at delivery, but not with the amount of weight gain during pregnancy, while fetal weight/uterine size did not seem predictive of developing GERD in pregnancy.
Journal ArticleDOI
Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease.
Karine Dal-Paz,Joaquim Prado P Moraes-Filho,Tomas Navarro-Rodriguez,Jaime Natan Eisig,Ricardo C. Barbuti,Eamonn Martin Quigley +5 more
TL;DR: Adherence to proton pump inhibitor (PPI) treatment and associated variables in patients with gastroesophageal reflux disease was correlated with demographics, cotherapies, comorbidities, treatment duration, symptoms scores, endoscopic findings, and patient awareness of their disease.
Journal ArticleDOI
Persistence of Nonceliac Wheat Sensitivity, Based on Long-term Follow-up
Antonio Carroccio,Alberto D'Alcamo,Giuseppe Iacono,Maurizio Soresi,Rosario Iacobucci,A. Arini,Girolamo Geraci,Francesca Fayer,Francesca Cavataio,Francesco La Blasca,Ada Maria Florena,Pasquale Mansueto +11 more
TL;DR: It is concluded that nonceliac wheat sensitivity is a persistent condition and patients who adhered strictly to a gluten-free diet had reduced symptoms after a diagnosis.
Journal ArticleDOI
Amerindian mtDNA haplogroups and celiac disease risk HLA haplotypes in mixed-blood Latin American patients.
Alejandra Parada,Magdalena Araya,Francisco Pérez-Bravo,Marco A. Méndez,Adriana Mimbacas,Patricia Motta,Gabriela Martín,Jorge Botero,Nelly Espinosa,Teresa Alarcón,Paulina Canales +10 more
TL;DR: In this article, the authors measured the frequency of Amerindian mtDNA haplogroups (inherited by the maternal line) in mixed-blood patients with celiac disease from Chile, Argentina, and Uruguay, and assessed the relation between these and human leukocyte antigen (HLA) alleles and haplotypes and clinical presentations.