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Xylitol Down-Regulates 1α,25-Dihydroxy Vitamin D3-induced Osteoclastogenesis via in Part the Inhibition of RANKL Expression in Osteoblasts
Seung-Ho Ohk,Hyunjoo Jeong,Jong-Pill Kim,Yun-Jung Yoo,Jeong Taeg Seo,Dong Min Shin,S.H. Lee +6 more
- Vol. 38, Iss: 3, pp 127-134
TLDR
Xylitol Down-Regulates 1α,25-Dihydroxy Vitamin D3-induced Osteoclastogenesis via in Part the Inhibition of RANKL Expression in OsteoblastsAbstract:
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Xylitol Down-Regulates 1α,25-Dihydroxy Vitamin D3-induced Osteoclastogenesis via in Part the Inhibition of RANKL Expression in Osteoblastsread more
Citations
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A review on osteoclast diseases and osteoclastogenesis inhibitors recently developed from natural resources.
TL;DR: Osteoclast-related diseases, such as osteoporosis, rheumatoid arthritis, Paget's disease, osteoclastoma, and periprosthetic osteolysis, are currently the most common reasons for bone inflammation, pain and fractures, resulting in low quality of life.
Bumetanide, the specific inhibitor of Na+-K+-2C1- cotransport, inhibits 1α,25-dihydroxyvitamin D3-induced osteoclastogenesis in a mouse co-culture system
Hyun-A Lee,Hyunjoo Jeong,S.H. Lee,Seung-Ho Ohk,Dong Min Shin,Jeong Taeg Seo,Yun-Jung Yoo,Mi Young Nam,Eun Young Kim +8 more
TL;DR: In this article, a co-culture system was used to investigate the mechanism by which bumetanide inhibits osteoclastogenesis, and the mRNA expressions of the receptor activator of nuclear factor (NF)−κB ligand (RANKL) and osteoprotegerin (OPG) were analysed by RT-PCR.
References
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Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
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TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells*
Brian Wong,Jaerang Rho,Joseph R. Arron,Elizabeth Robinson,Jason R. Orlinick,Moses V. Chao,Sergey Kalachikov,Eftihia Cayani,Frederick S. Bartlett,Wayne N. Frankel,Soo Young Lee,Yongwon Choi +11 more
TL;DR: A role for this TNF-related ligand in the regulation of the T cell-dependent immune response is suggested.
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The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts
Teresa L. Burgess,Yi-xin Qian,Stephen Kaufman,Brian D. Ring,Gwyneth Van,C. Capparelli,Michael J. Kelley,Hailing Hsu,William J. Boyle,Colin R. Dunstan,Sylvia Hu,David L. Lacey +11 more
TL;DR: Findings indicate that, in addition to their effects on OC precursors, OPGL and OPG have profound and direct effects on mature OCs and indicate that the OC receptor, RANK, mediates OPGl's effects.
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Cellular mechanisms of bone remodeling
TL;DR: Bone remodeling is a tightly regulated process securing repair of microdamage (targeted remodeling) and replacement of old bone with new bone through sequential osteoclastic resorption and osteoblastic bone formation.