B
B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
Papers
More filters
Journal ArticleDOI
Gut microbiota-mediated protection against diarrheal infections
Stefanie L. Vogt,B. Brett Finlay +1 more
TL;DR: Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens.
Journal ArticleDOI
Are noncommunicable diseases communicable
TL;DR: It is proposed that some NCDs could have a microbial component and, if so, might be communicable via the microbiota.
Journal ArticleDOI
Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome.
Lisa A. Reynolds,Lisa A. Reynolds,Stephen A. Redpath,Sophie Yurist-Doutsch,Navkiran Gill,Eric M. Brown,Joris van der Heijden,Tara P. Brosschot,Jun Han,Natalie C. Marshall,Sarah E Woodward,Yanet Valdez,Christoph H. Borchers,Georgia Perona-Wright,Georgia Perona-Wright,B. Brett Finlay +15 more
TL;DR: It is shown that an ongoing helminth infection increased colonization by Salmonella independently of T regulatory or Th2 cells, which reveals a novel mechanism by which a helminths-modified metabolome promotes susceptibility to bacterial coinfection.
Journal ArticleDOI
Mechanical fractionation reveals structural requirements for enteropathogenic Escherichia coli Tir insertion into host membranes.
TL;DR: A mechanical method of cell lysis and ultracentrifugation is applied to fractionate infected HeLa cells to investigate the biology and biochemistry of Tir delivery and translocation and demonstrates that the translocation of Tir requires its transmembrane domains, but not tyrosine phosphorylation or binding to Tir's ligand, intimin.
Journal ArticleDOI
Introduction: microbiology and immunology: lessons learned from Salmonella.
TL;DR: This multidisciplinary research will enhance the understanding of the basic mechanisms of bacterial infections and immunity; it also provides new approaches towards therapeutic and control measures.