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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Locus of Enterocyte Effacement from Citrobacter rodentium: Sequence Analysis and Evidence for Horizontal Transfer among Attaching and Effacing Pathogens
TL;DR: The results indicate that the full DNA sequence of C.rodentium LEE has been acquired by C. rodentium and A/E E.coli strains independently during evolution.
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The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells.
Olivia Steele-Mortimer,John H. Brumell,Leigh A. Knodler,Stéphane Méresse,Ana Sofia Lopez,B. Brett Finlay +5 more
TL;DR: A previously unknown role for SPI‐1 in vacuole biogenesis and intracellular survival in non‐phagocytic cells is demonstrated.
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Salmonella typhimurium Infection and Lipopolysaccharide Stimulation Induce Similar Changes in Macrophage Gene Expression
TL;DR: It is found that S. typhimurium infection caused significant changes in the expression of numerous genes encoding chemokines, cell surface receptors, signaling molecules, and transcriptional activators of the RAW 264.7 murine macrophage cell line, indicating that host cell responses depend on the activation state of the cell.
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Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals.
Daniel Kalman,Orion D. Weiner,Danika L. Goosney,John W. Sedat,B. Brett Finlay,Arie Abo,J. Michael Bishop +6 more
TL;DR: This is, to the authors' knowledge, the first demonstration of cellular mediators of EPEC pedestal formation and of localized recruitment of WASP and Arp2/3c as part of a signalling cascade initiated at the cell surface.
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Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
Eric M. Brown,Xiaobo Ke,Daniel S. Hitchcock,Sarah Jeanfavre,Julian Avila-Pacheco,Toru Nakata,Timothy D. Arthur,Nadine Fornelos,Cortney E. Heim,Eric A. Franzosa,Nicki Watson,Curtis Huttenhower,Curtis Huttenhower,Henry J. Haiser,Glen Dillow,Daniel B. Graham,B. Brett Finlay,Aleksandar Kostic,Jeffrey A. Porter,Hera Vlamakis,Hera Vlamakis,Clary B. Clish,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier +24 more
TL;DR: The role of bacterial sphingolipids in maintaining homeostasis and symbiosis in the gut is highlighted and lower abundances in IBD and negative correlations with inflammation and host sphingoipid production are revealed.