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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
The art of bacterial warfare.
TL;DR: The article reports on research into pathogenic bacteria, focusing on the evolutionary relationships between bacterial behaviors and toxins, and the immune systems of their hosts, to find out the mechanisms by which microorganisms cause damage in humans.
Journal ArticleDOI
In vitro Real-time Measurement of the Intra-bacterial Redox Potential
TL;DR: This protocol describes a method for the measurement of real-time changes to the intra-bacterial redox potential using redox-sensitive GFP (roGFP2) (van der Heijden et al., 2015) and can be adjusted for use in other Gram-negative bacteria.
Journal ArticleDOI
Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin.
TL;DR: A definitive phenotypic impairment of innate response in mice lacking PSGL‐1 or P‐selectin is demonstrated, and it is suggested that these adhesion molecules are important in host innate immune response against Citrobacter infection.
Journal ArticleDOI
Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-γ-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1
Narveen Jandu,Songhai Shen,Mark Wickham,Rohit Prajapati,B. Brett Finlay,Mohamed A. Karmali,Philip M. Sherman +6 more
TL;DR: Inhibition of interferon-gamma stimulated Stat1-tyrosine phosphorylation by VTEC of multiple seropathotypes indicates the presence of a common inhibitory factor that is independent of bacterial virulence in humans.
Book ChapterDOI
Bacterial Adherence, Colonization, and Invasion of Mucosal Surfaces
John H. Brumell,B. Brett Finlay +1 more
TL;DR: This chapter provides a brief overview of the pathogenic strategies of some bacteria that infect the mucosal surface of the intestinal tract and focuses on two model systems for the study of bacterial pathogens that cause disease by colonizing (enteropathogenic Escherichia coli] or penetrating (Salmonella species) the intestinal epithelium.