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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
Stephanie R. Shames,Wanyin Deng,Julian A. Guttman,Carmen L. de Hoog,Yuling Li,Philip R. Hardwidge,Ho Pan Sham,Bruce A. Vallance,Leonard J. Foster,B. Brett Finlay +9 more
TL;DR: Evidence that EspZ and CD98 promote host cell survival mechanisms involving FAK during A/E pathogen infection is provided, which contributes to protection against EPEC‐mediated cytotoxicity.
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Should the Human Microbiome Be Considered When Developing Vaccines
TL;DR: The microbiota could be an underappreciated yet important player to consider in the development of vaccines, and also may help explain some of the discrepancies observed in vaccine efficacy in different populations around the world.
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Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma
Leah T. Stiemsma,Marie-Claire Arrieta,Pedro A. Dimitriu,Jasmine Z. Cheng,Lisa Thorson,Diana L. Lefebvre,Meghan B. Azad,Padmaja Subbarao,Padmaja Subbarao,Piush J. Mandhane,Allan B. Becker,Malcolm R. Sears,Tobias R. Kollmann,William W. Mohn,B. Brett Finlay,Stuart E. Turvey +15 more
TL;DR: It is concluded that opposing shifts in the relative abundances of Lachnospira and C. neonatale in the first 3 months of life are associated with preschool age asthma, and that the L/C ratio may serve as a potential early life biomarker to predict asthma development.
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Isolation and characterization of Salmonella typhimurium and Yersinia pseudotuberculosis-containing phagosomes from infected mouse macrophages: Y. pseudotuberculosis traffics to terminal lysosomes where they are degraded
Scott D. Mills,B. Brett Finlay +1 more
TL;DR: The described method for isolation and characterization of BCVs proved to be a valuable tool to characterize the vacuolar compartment occupied by Y. pseudotuberculosis, and has potential to be applied to other vacuole resident pathogens whose trafficking is thought to play a role in pathogenesis.
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Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage.
Brian K. Coombes,Mark Wickham,Nathaniel Francis Brown,Sebastien Lemire,Lionello Bossi,William W. L. Hsiao,Fiona S. L. Brinkman,B. Brett Finlay +7 more
TL;DR: The temperate bacteriophage called Gifsy-1 in S.enterica serovar Typhimurium is investigated and it is shown that the product of the gogB gene encoded within this phage shares similarity with proteins from other Gram-negative pathogens.