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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice
Mohammed A. Khan,Caixia Ma,Leigh A. Knodler,Yanet Valdez,Yanet Valdez,Carrie M. Rosenberger,Wanyin Deng,B. Brett Finlay,Bruce A. Vallance +8 more
TL;DR: Impaired TLR4-mediated responses against this A/E pathogen are not host protective and are ultimately maladaptive to the host, contributing to both the morbidity and the pathology seen during infection.
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Disruption of the Salmonella-Containing Vacuole Leads to Increased Replication of Salmonella enterica Serovar Typhimurium in the Cytosol of Epithelial Cells
TL;DR: The requirement of the host cell endosomal system for maintenance of the SCV is demonstrated and that loss of this compartment allows increased replication of serovar Typhimurium in the cytosol of epithelial cells.
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Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.
Akio Abe,Myriam de Grado,Richard A. Pfuetzner,Claudia Sánchez-SanMartı́n,Rebekah DeVinney,José L. Puente,José L. Puente,Natalie C. J. Strynadka,B. Brett Finlay +8 more
TL;DR: Results indicate that CesT is a Tir chaperone that may act as an anti‐degradation factor by specifically binding to its amino‐terminus, forming a multimeric stabilized complex.
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The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization.
Rosana B. R. Ferreira,Navkiran Gill,Benjamin P. Willing,L. Caetano M. Antunes,Shannon L. Russell,Matthew A. Croxen,B. Brett Finlay +6 more
TL;DR: There is a strong correlation between the intestinal microbiota composition before infection and susceptibility to Salmonella-induced colitis, and members of the Bacteroidetes phylum were present at significantly higher levels in mice resistant to colitis.
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Phage display: applications, innovations, and issues in phage and host biology.
Dan R. Wilson,B. Brett Finlay +1 more
TL;DR: In the 7 years since the first publications describing phage-displayed peptide libraries, phage display has been successfully employed in a variety of research and the limitations and considerable potential of this important technology are reviewed.