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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD
Lone S. Bertelsen,Günther Paesold,Sandra L. Marcus,B. Brett Finlay,Lars Eckmann,Kim E. Barrett +5 more
TL;DR: The Salmonella bacterial effector protein SigD may play critical roles in the pathogenesis of disease caused by this microorganism, and an early role for SigD in reducing barrier function, perhaps via activation of protein kinase C.
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Host immune response to antibiotic perturbation of the microbiota.
Marta Wlodarska,B. Brett Finlay +1 more
TL;DR: Dysregulation of the homeostasis between mammals and their intestinal symbionts has been shown to predispose the host to enteric infection, and may lead to development of inflammatory bowel diseases.
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In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections.
TL;DR: This work describes how EPEC and EHEC attach to host cells and subvert host-cell signaling pathways to promote infection and cause disease and suggests new therapeutic strategies to help control these significant enteric pathogens.
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Virulence is positively selected by transmission success between mammalian hosts.
TL;DR: This work quantifies the contribution of virulence determinants to the evolutionary success of a pathogen and shows that virulence factors provide a selective advantage by enhancing transmission between hosts.
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Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses.
TL;DR: How bacterial pathogens use an arsenal of secreted virulence proteins to modify the outcome of innate immune activation by altering how the immune system recognizes microbial invaders is discussed.