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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers.
TL;DR: Data indicate that EPEC causes a decrease in transepithelial electrical resistance by disrupting a transcellular (intracellular) pathway rather than by disrupting intercellular tight junctions (paracellular) and that these disruptions occur only when attaching and effacing lesions are formed.
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Pathogenic trickery: deception of host cell processes
TL;DR: A large number of pathogens have developed virulence factors that interact with host molecules, often usurping normal cellular processes, and mediate events as diverse as bacterial invasion, antiphagocytosis, and intracellular parastism.
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Salmonella: from pathogenesis to therapeutics.
TL;DR: This review will highlight some of the central themes that arose during the course of the conference, as it is so brief, it will describe only a fraction of the many excellent talks and posters presented.
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Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.
Raymond H. See,Alexander N. Zakhartchouk,Martin Petric,David Lawrence,Catherine P. Y. Mok,Robert J. Hogan,Thomas Rowe,Lois A. Zitzow,Karuna P. Karunakaran,Mary Hitt,Frank L. Graham,Ludvik Prevec,James B. Mahony,Chetna Sharon,Thierry C. Auperin,James M. Rini,Aubrey J. Tingle,David W. Scheifele,Danuta M. Skowronski,David M. Patrick,Thomas G. Voss,Lorne A. Babiuk,Jack Gauldie,Rachel L. Roper,Robert C. Brunham,B. Brett Finlay +25 more
TL;DR: The whole killed virus (WKV) vaccine given subcutaneously to 129S6/SvEv mice was more effective than the Ad S/N vaccine administered either intranasally or intramuscularly in inhibiting SARS-CoV replication in the murine respiratory tract.
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A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and GrlA
Jeannette Barba,Víctor H. Bustamante,Mario Alberto Flores-Valdez,Wanyin Deng,B. Brett Finlay,José L. Puente +5 more
TL;DR: The results indicate that Ler and GrlA induce the expression of each other by, at least in part, counteracting the repression mediated by H-NS, revealing a novel regulatory loop controlling the optimal expression of virulence genes in A/E pathogens.