B
B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
Papers
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Journal ArticleDOI
Bacterial pathogenesis: The answer to virulence is in the pore
Annick Gauthier,B. Brett Finlay +1 more
TL;DR: A wide variety of Gram-negative bacterial pathogens use a 'type III' protein secretion system to deliver bacterial virulence factors into host cells, and recent results suggest that Gram-positive pathogens may employ similar methods.
Journal ArticleDOI
Persistent Salmonella enterica Serovar Typhimurium Infection Induces Protease Expression During Intestinal Fibrosis.
Katrin Ehrhardt,Natalie Steck,Reinhild Kappelhoff,Stephanie Stein,Florian Rieder,Ilyssa O. Gordon,Erin C. Boyle,Peter Braubach,Christopher M. Overall,B. Brett Finlay,Guntram A. Grassl +10 more
TL;DR: It is shown that chronic Salmonella infection regulates proteases and protease inhibitors during tissue fibrosis in vivo and in vitro, and therefore this model is well suited to investigating the role of proteases in intestinal fibrosis.
Journal ArticleDOI
Chemical signaling in the gastrointestinal tract
TL;DR: There may be a wealth of unidentified bioactive small molecules in the human body, originating from both microbial and human cells and that have important biological functions that could be used for human benefit.
Journal ArticleDOI
Differential post-transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolates
Andrew J. Pollard,Andrew J. Currie,Carrie M. Rosenberger,John-Paul Heale,B. Brett Finlay,David P. Speert +5 more
TL;DR: The results indicate that strains of the same species of bacteria may induce differential macrophage phagocytic and inflammatory responses with likely consequence for bacterial clearance and host injury.
Patent
Methods of stimulating innate immunity using cationic peptides
Robert E. W. Hancock,B. Brett Finlay,Monisha G. Scott,Dawn M. E. Bowdish,Carrie M. Rosenberger,Jon-Paul S. Powers +5 more
TL;DR: In this article, a method of identifying a polynucleotide or pattern of polyn nucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described.