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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
Papers
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Journal ArticleDOI
Nutrient Deprivation Affects Salmonella Invasion and Its Interaction with the Gastrointestinal Microbiota.
Sophie Yurist-Doutsch,Marie-Claire Arrieta,Audrey Tupin,Yanet Valdez,L. Caetano M. Antunes,Ryan Yen,B. Brett Finlay +6 more
TL;DR: It is demonstrated that S. Typhimurium remains a potent pathogen even in the face of nutritional deprivation, but nevertheless that nutrient deprivation encountered in this environment elicits significant changes in the bacterium genetic programme, as well as its capacity to alter host microbiota composition.
Book ChapterDOI
Cell Biology of Salmonella Pathogenesis
TL;DR: This chapter focuses on the events that occur in the host cell rather than to focus on the bacterial genes that mediate these events, which have revealed several interesting processes and provided new tools for the study of eukaryotic cell function.
Journal ArticleDOI
Leaky guts and lipid rafts.
Erin C. Boyle,B. Brett Finlay +1 more
TL;DR: There is compelling evidence that several intestinal diseases are associated with the translocation of commensal bacteria across the epithelial barrier, and a novel mechanism by which normally non-invasive enteric bacteria breach the intestinal epithelium during periods of inflammation is identified.
Journal ArticleDOI
Identification and Regulation of a Novel Citrobacter rodentium Gut Colonization Fimbria (Gcf)
Gustavo Caballero-Flores,Matthew A. Croxen,Verónica I. Martínez-Santos,B. Brett Finlay,José L. Puente +4 more
TL;DR: The identification of a novel C. rodentium colonization factor, called gut colonization fimbria (Gcf), which is encoded by a chaperone-usher fimbrial operon that is important for early establishment of a successful infection by C. rodents in mice.
Patent
Bacterial compositions and methods of use thereof
TL;DR: In this article, the authors present a method of using two or more bacteria of the genera Faecalibacterium, Lachnospira, Veillonella or Rothia for treating gut dysbiosis, asthma, allergy or atopy.