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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens
B. Brett Finlay,Grant McFadden +1 more
TL;DR: This review highlights and compares some of the many molecular mechanisms that bacterial and viral pathogens use to evade host immune defenses.
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Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma
Shannon L. Russell,Matthew J. Gold,Martin Hartmann,Benjamin P. Willing,Lisa Thorson,Marta Wlodarska,Navkiran Gill,Marie-Renée Blanchet,William W. Mohn,Kelly M. McNagny,B. Brett Finlay +10 more
TL;DR: Data support a neonatal, microbiota‐driven, specific increase in susceptibility to experimental murine allergic asthma, consistent with the ‘hygiene hypothesis’.
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Soluble CD14 participates in the response of cells to lipopolysaccharide.
Elizabeth A. Frey,D S Miller,T G Jahr,Anders Sundan,V Bazil,Terje Espevik,B. Brett Finlay,Samuel D. Wright +7 more
TL;DR: It is shown that sCD14 enables responses to LPS by cells that do not express CD14, suggesting that a surface anchor is not needed for the function of CD14 and implying that s CD14 must bind to additional proteins on the cell surface to associate with the cell and transduce a signal.
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The Intestinal Microbiome in Early Life: Health and Disease
TL;DR: A greater understanding of how the early-life gut microbiota impacts the authors' immune development could potentially lead to novel microbial-derived therapies that target disease prevention at an early age.
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Salmonella, the host and disease: a brief review
TL;DR: This review explores some of the host and pathogenic mechanisms mobilized in the two predominant clinical syndromes associated with infection with Salmonella enterica species: enterocolitis and typhoid.