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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Enteropathogenic Escherichia coli type III effectors alter cytoskeletal function and signalling in Saccharomyces cerevisiae.
Isabel Rodríguez-Escudero,Philip R. Hardwidge,César Nombela,Víctor J. Cid,B. Brett Finlay,María Molina +5 more
TL;DR: The application of Saccharomyces cerevisiae as a model to probe the functions of LEE-encoded genes was described and it was concluded that the C-terminal region of the protein is necessary for actin disruption and toxicity, but not for mitochondrial localization.
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NAFLD and the Gut-Liver Axis: Exploring an Undernutrition Perspective.
TL;DR: Undernutrition conditions with fatty liver features, including kwashiorkor and micronutrient deficiency are presented and the gut microbiota-liver axis is reviewed, highlighting key pathways linked to NAFLD progression within both overnutrition and undernutrition.
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A humanized microbiota mouse model of ovalbumin-induced lung inflammation.
Marie-Claire Arrieta,Manish Sadarangani,Eric M. Brown,Shannon L. Russell,Michael Nimmo,John M. Dean,Stuart E. Turvey,Edmond S. Chan,B. Brett Finlay +8 more
TL;DR: It is demonstrated that there is no association between the composition of the gut microbiota in older children and the diagnosis of asthma, further suggesting the importance of the Gut microbiota-immune system axis in the first 3 months of life.
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Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project
Pascale Vonaesch,Rindra Randremanana,Jean-Chrysostome Gody,Jean-Marc Collard,Tamara Giles-Vernick,Maria Doria,Inès Vigan-Womas,Pierre-Alain Rubbo,Aurélie Etienne,Emilson Jean P R Andriatahirintsoa,Nathalie Kapel,Eric M. Brown,Kelsey E. Huus,Darragh Duffy,B. Brett Finlay,Milena Hasan,Francis Allen Hunald,Annick Robinson,Alexandre Manirakiza,Laura Wegener-Parfrey,Muriel Vray,Philippe J. Sansonetti +21 more
TL;DR: AFRIBIOTA will add new insights into the pathophysiology underlying stunting and PEE and in doing so will enable implementation of new biomarkers and design of evidence-based treatment strategies for these two syndromes.
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Initial Gut Microbial Composition as a Key Factor Driving Host Response to Antibiotic Treatment, as Exemplified by the Presence or Absence of Commensal Escherichia coli.
Tingting Ju,Yasmeen Shoblak,Yanhua Gao,Kaiyuan Yang,Janelle M Fouhse,B. Brett Finlay,Yee Wing So,Paul Stothard,Benjamin P. Willing +8 more
TL;DR: The results of this proof-of-concept study indicate that even minor variations in initial commensal microbiota can drive shifts in microbial composition and host response after antibiotic administration, and encourage the development of personalized medication in antibiotic therapies.